Dynamika biologických procesů

Dynamika biologických procesů

Gustavo Fuertes Vives

Gustavo Fuertes Vives — Vedoucí projektu

O nás

The project is focused on the analysis of ultra-fast dynamics (<10 picoseconds) of biological molecular systems using unique pulsed sources of ionizing radiation of the ELI Beamlines infrastructure.

The project is closely connected with projects 3.6 in the complex biophysical characterization of the studied systems and with project 3.9 in the interpretation of measured data by quantum mechanical and other computer models.

 

Objectives:

  • Mechanistic explanation of the correlation between dynamics and functions of the studied systems by correlations of structural changes with their time course
  • Explanation of mechanisms of ionization damage of proteins and nucleic acids

More information about the group can be found on the English version of the site.

Aktuality

Publikace

2021

Andrikopoulos, P. C.; Chaudhari, A.S.; Liu, Y.; Konold, P.E.; Kennis, J.T.M.; Schneider, B.; Fuertes, G. QM Calculations Predict the Energetics and Infrared Spectra of Transient Glutamine Isomers in LOV Photoreceptors. Phys. Chem. Chem. Phys. PCCP 2021. https://doi.org/10.1039/d1cp00447f.

Pham, P. N.; Huličiak, M.; Biedermannová, L.; Černý, J.; Charnavets, T.; Fuertes, G.; Herynek, Š.; Kolářová, L.; Kolenko, P.; Pavlíček, J.; Zahradník, J.; Mikulecky, P.; Schneider, B. Protein Binder (ProBi) as a New Class of Structurally Robust Non-Antibody Protein Scaffold for Directed Evolution. Viruses 2021, 13 (2). https://doi.org/10.3390/v13020190.

 
2020

Andrikopoulos P. C.; Liu Y.; Picchiotti A.; Lenngren N.; Kloz M.; Chaudhari A. S.; Precek M.; Rebarz M.; Andreasson J.; Hajdu J.; Schneider B.; Fuertes G.; Femtosecond-to-Nanosecond Dynamics of Flavin Mononucleotide Monitored by Stimulated Raman Spectroscopy and Simulations, PCCP 2020, https://doi.org/10.1039/C9CP04918E

2019

Fuertes, G., Nevola, L., and Esteban-Martin, S. (2019). Perspectives on drug discovery strategies based on IDPs in Intrinsically Disordered Proteins: Dynamics, Binding, and Function, Academic Press, pp. 275-327. https://doi.org/10.1016/B978-0-12-816348-1.00009-0

2018

Fuertes, G., Banterle, N., Ruff, K.M., Chowdhury, A., Pappu, R.V., Svergun, D.I., and Lemke,E.A (2018). Comment on “Innovative scattering analysis shows that hydrophobic disordered proteins are expanded in water.” Science 361 (6405). https://doi.org/10.1126/science.aau8230

2017

Fuertes, G., Banterle, N., Ruff, K.M., Chowdhury, A., Mercadante, D., Koehler, C., et al. (2017). Decoupling of size and shape fluctuations in heteropolymeric sequences reconciles discrepancies in SAXS vs. FRET measurements. Proc. Natl. Acad. Sci. 114, E6342–E6351. https://doi.org/10.1073/pnas.1704692114

Tým

Gustavo Fuertes Vives Gustavo Fuertes Vives

Gustavo Fuertes Vives

Vedoucí skupiny Dynamika biologických procesů

gustavo.fuertes@ibt.cas.cz
+420325873739
prof. Ing. Bohdan Schneider, CSc., DSc prof. Ing. Bohdan Schneider, CSc., DSc

prof. Ing.
Bohdan Schneider, CSc., DSc

ředitel, Biotechnologický ústav AV ČR, v.v.i.,
vedoucí výzkumného programu Strukturní biologie a proteinové inženýrství,
vedoucí skupiny Intermolekulární rozpoznávání proteinů a nukleových kyselin

bohdan.schneider@ibt.cas.cz
+420325873701
Inger Agneta Andersson Inger Agneta Andersson

Inger Agneta Andersson

Senior Scientist

inger.andersson@ibt.cas.cz
+420325873739

Výuka

Alumni

jméno název práce typ práce termín
Gina Göritz
Natalie Huhn
Catarina Alexandra Oliveira Domingos

Nabízená témata VŠ kvalifikačních prací

jméno název práce typ práce
Aditya Suresh Chaudhari
Aditi Chatterjee
Theresa Heinrich
Edel Cunill Semanat