Strukturní neurobiologie

Strukturní neurobiologie

Mgr. Daniel Rozbeský, Ph.D.

Mgr. Daniel Rozbeský, Ph.D. — Vedoucí projektu

Přírodovědecká fakulta Univerzity Karlovy

O nás

Molecular mechanisms of axon guidance

We are a newly established group at Biocev. Our research focuses on signalling molecules and cell surface receptors that play central roles in neurobiology and have relevance to translational medicine. Currently, we have a particular interest in studying signalling molecules and mechanisms underlying cell guidance and nervous system wiring. Our efforts are focused on the structural biology and molecular mechanisms of MICAL signalling in cytoskeletal dynamics


More info HERE




Mehta V, Pang KL, Rozbesky D, Nather K, Keen A, Lachowski D, Kong Y, Karia D, Ameismeier M, Huang J, Fang Y, Del Rio Hernandez A, Reader JS, Jones EY, Tzima E (2020). The guidance receptor Plexin D1 moonlights as an endothelial mechanosensor. Nature. 578: 290-295

Rozbesky D, Monistrol J, Jain V, Hillier J, Padilla-Parra S, Jones EY (2020). Drosophila OTK is a glycosaminoglycan-binding protein with high conformational flexibility. Structure. 28: 507-515.

Rozbesky D, Verhagen MG, Karia D, Nagy GN, Alvarez L, Harlos K, Padilla-Parra S, Pasterkamp RJ, Jones EY. Structural basis of semaphorin-plexin cis interaction. EMBO J. 39: e102926


Rozbesky D, Robinson RA, Jain V, Renner M, Malinauskas T, Harlos K, Siebold C, Jones EY (2019). Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning. Nat Commun. 10: 3691-3703.


Walters LC, Harlos K, Brackenridge S, Rozbesky D, Barrett J, Jain V, O’Callaghan C, Borrow P, Toebes M, Hansen SG, Sacha J, Abdulhaqq S, Greene JM, Fruh K, Marshall E, Picker LJ, Jones EY, McMichael AJ, Gillespie GM (2018) Pathogen-derived HLA bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding. Nat Commun. 9: 3137-3150