Centrum výzkumu patogenity a virulence parazitů

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Kulkarni S., Rubio M. A. T., Hegedüsová E., Ross R. L., Limbach P. A., Alfonzo J. D., Paris Z. Preferential import of queuosine-modified tRNAs into Trypanosoma brucei mitochondrion is critical for organellar protein synthesis. Nucleic Acids Research, Volume 49, Issue 14, 20 August 2021. Pages 8247–8260, https://doi.org/10.1093/nar/gkab567

Paris Z., Svobodová M., Kachale A., Horáková E., Nenarokova A. & Lukeš J. (2021). A mitochondrial cytidine deaminase is responsible for C to U editing of tRNATrp to decode the UGA codon in Trypanosoma brucei. RNA Biology, 18:sup1, 278-286. DOI: 10.1080/15476286.2021.1940445

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Smilansky V., Jirků M., Milner D. S., Ibáñez R., Gratwicke B., Nicholls A., Lukeš J., Chambouvet A. & Richards T. A. (2021). Expanded host and geographic range of tadpole associations with the Severe Perkinsea infection group. Volume 17, Issue 6. https://doi.org/10.1098/rsbl.2021.0166

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Pyrih J., Pánek T., Durante I. M., Rašková V., Cimrhanzlová K., Kriegová E., Tsaousis A. D., Eliáš M., Lukeš J. Vestiges of the bacterial signal recognition particle-based protein targeting in mitochondria. Molecular Biology and Evolution, Volume 38, Issue 8, August 2021, Pages 3170–3187, https://doi.org/10.1093/molbev/msab090

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Turnšek J., Brunson J. K., del Pilar Martinez Viedma M., Deerinck T. J., Horák A., Oborník M., Bielinski V. A., Allen A. E. (2021) Proximity proteomics in a marine diatom reveals a putative cell surface-to-chloroplast iron trafficking pathway. eLife 10:e52770. https://doi.org/10.7554/eLife.52770

Padilla-Mejia N. E., Koreny L., Holden J., Vancová M., Lukeš J., Zoltner M., Field M. C. A hub-and-spoke nuclear lamina architecture in trypanosomes. J Cell Sci. 2021 Jun 15;134(12):jcs251264. 

Sharma P. P., Kumar S., Srivastava S., Srivastava M., Jee B., Gorobets N. Y., Kumar D., Kumar M., Asthana S., Zhang P., Poonam, Zoltner M., Rathi B. Computational study of novel inhibitory molecule, 1-(4-((2S,3S)-3-amino-2-hydroxy-4-phenylbutyl)piperazin-1-yl)-3-phenylurea, with high potential to competitively block ATP binding to the RNA dependent RNA polymerase of SARS-CoV-2 virus. J Biomol Struct Dyn. 2021 Jun 21:1-19. 

Hammond M., Zoltner M., Garrigan J., Butterfield E., Varga V., Lukeš J., Field M. C. The distinctive flagellar proteome of Euglena gracilis illuminates the complexities of protistan flagella adaptation. New Phytol. 2021 Jul 22.

Vorel J., Cwiklinski K., Roudnický P., Ilgová J., Jedličková L., Dalton J. P., Mikeš L., Gelnar M., Kašný M. (2021): Eudiplozoon nipponicum (Monogenea, Diplozoidae) and its adaptation to haematophagy as revealed by transcriptome and secretome profiling. BMC Genomics 22: 274. DOI: 10.1186/s12864-021-07589-z [IF2020=3.969]

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Kniha E., Milchram M., Dvorak V., Halada P., Obwaller A. G., Poeppl W., Mooseder G., Volf P., Walochnik J. (2021). Ecology, seasonality and host preferences of Austrian Phlebotomus (Transphlebotomus) mascittii Grassi, 1908, populations. PARASITES & VECTORS 14: Article Number 291.

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Ashwin H., Sadlova J., Vojtkova B., Becvar T., Lypaczewski P., Schwartz E., Greensteed E., Van Boxlaer K., Parin M., Lipinski K. S., Parkash V., Matlashewski G., Layton A. M., Lacey C. J., Jaffe C. L., Volf P., Kay P. M. (2021). Characterization of a new Leishmania major strain for use in a controlled human infection model. Nature Communications 12: 215.

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Votýpka J., Petrželková K. J., Brzoňová J., Jirků M., Modrý D. & Lukeš J. (2021) How monoxenous trypanosomatids revealed hidden feeding habits of their tsetse fly hosts. Folia Parasitologica 68: 019.

Belinky F., Ganguly I., Poliakov E., Yurchenko V., Rogozin I. B. Analysis of stop codons within prokaryotic protein-coding genes suggests frequent readthrough events. Int. J. Mol. Sci., 2021, 22: 1876.

Lukeš J., Tesařová M., Yurchenko V., Votýpka J. Characterization of a new cosmopolitan genus of trypanosomatid parasites, Obscuromonas gen. nov. (Blastocrithidiinae subfam. nov.). Eur. J. Protistol., 2021, 79: 125778.

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Charyyeva A., Çetinkaya Ü., Özkan B., Şahin S., Yaprak N., Şahin I., Yurchenko V., Kostygov A. Y. Genetic diversity of Leishmania tropica: unexpectedly complex distribution pattern. Acta Trop., 2021, 218: 105888.

Albanaz A. T. S., Gerasimov E. S., Shaw J. J., Sádlová J., Lukeš J., Volf P., Opperdoes F. R., Kostygov A. Y., Butenko A., Yurchenko V. Genome analysis of Endotrypanum and Porcisia spp., closest phylogenetic relatives of Leishmania, highlights the role of amastins in shaping pathogenicity. Genes. 2021, 12(3): 444.

Gerasimov E. S., Gasparyan A. A., Afonin D. A., Zimmer S. L., Kraeva N., Lukeš J., Yurchenko V., Kolesnikov A. Complete minicircle genome of Leptomonas pyrrhocoris reveals a source of its non-canonical mitochondrial RNA editing events. Nucl. Acids Res., 2021, 49(6): 3354-3370.

Frolov A. O., Kostygov A. Y., Yurchenko V. Development of monoxenous trypanosomatids and phytomonads in insects. Trends Parasitol., 2021, 37(6): 538-551.

Skalický T., Alves J. M. P., Morais A. C., Režnarová J., Butenko A., Lukeš J., Serrano M. G., Buck G. A., Teixeira M. M. G., Camargo E. P., Sanders M., Cotton J. A., Yurchenko V., Kostygov A. Y. Endosymbiont capture, a repeated process of endosymbiont transfer with replacement in trypanosomatids Angomonas spp. Pathogens, 2021, 10: 702.

Konorov E. A., Yurchenko V., Patraman I. V., Lukashev A. N., Oyun N. Y. The effects of genetic drift and genomic selection on differentiation and local adaptation of the introduced populations of Aedes albopictus in southern Russia. Peer J., 2021, 9: e11776.

Barcytė D., Eikrem W., Engesmo A., Seoane S., Wohlmann J., Horák A., Yurchenko T., Eliáš M. Olisthodiscus represents a new class of Ochrophyta. J. Phycol., 2021, 57: 1094-1118.

Tice A. K., Žihala D., Pánek T., Jones R. J., Salomaki E., Nenarokov S., Burki F., Eliáš M., Eme L., Roger A. J., Rokas A., Shen X.-X., Strassert J. F. H., Kolísko M., Brown M. W. PhyloFisher: a phylogenomic package for resolving deep eukaryotic relationships. PLoS Biol., 2021, 19: e3001365.

Larue G. E., Eliáš M., Roy S. W. Expansion and transformation of the minor spliceosomal system in the slime mold Physarum polycephalum. Curr. Biol., 2021, 31: P3125-3131.E4.

Herman E. K., Greninger A., van der Giezen M., Ginger M. L., Ramirez-Macias I., Miller H. C., Morgan M. J., Tsaousis A. D., Velle K., Vargová R., Záhonová K., Najle S. R., MacIntyre G., Muller N., Wittwer M., Zysset-Burri D. C., Eliáš M., Slamovits C., Weirauch M., Fritz-Laylin L., Marciano-Cabral F., Puzon G. J., Walsh T., Chiu C., Dacks J. B. Genomics and transcriptomics yields a systems-level view of the biology of the pathogen Naegleria fowleri. BMC Biol., 2021, 19: 142.

Pyrih J., Žárský V., Fellows D.J., Grosche C., Wloga D., Striepen B, Maier G.U., Tachezy J. 2021. The iron-sulfur scaffold protein HCF101 unveils the complexity of organellar evolution in SAR, Haptista and Cryptista. BMC Evolutionary Biology 21, Article number: 46 (2021)

Žárský V., Klimeš V., Pačes J., Vlček Č, Hradilová M., Beneš V., Nývltová E., Hrdý I., Pyrih J, Mach J., Barlow L., Stairs C.W., Eme L., Hall N., Eliáš M., Dacks BJ, Roger A., Tachezy J. 2021. The Mastigamoeba balamuthi genome and the nature of the free-living ancestor of Entamoeba. Mol. Biol. Evol. doi: 10.1093/molbev/msab020. Online ahead of print. PMID: 33528570, IF 11,062

Bensaoud Ch., Martins L. A., Aounallah H., Hackenberg M., Kotsyfakis M. Emerging roles of non-coding RNAs in vector-borne infections. J Cell Sci (2021) 134 (5): jcs246744. https://doi.org/10.1242/jcs.246744

Villafraz O., Biran M., Pineda E., Plazolles N., Cahoreau E., Ornitz Oliveira Souza R., et al. (2021) Procyclic trypanosomes recycle glucose catabolites and TCA cycle intermediates to stimulate growth in the presence of physiological amounts of proline. PLoS Pathog 17(3): e1009204. https://doi.org/10.1371/journal.ppat.1009204

Kostygov A.Y., Karnkowska A., Votýpka J., Tashyreva D., Maciszewski K., Yurchenko V. & Lukeš J. (2021) Euglenozoa: taxonomy, diversity and ecology, symbioses and viruses. Open Biology 11: 200407.

Horváthová L., Žárský V., Pánek T., Derelle R., Pyrih J., Motyčková A., Klápšťová V., Vinopalová M., Marková L., Voleman L., Klimeš V., Petrů M., Vaitová Z., Čepička I., Hryzáková K., Harant K., Gray M. W., Chami M., Guilvout I., Francetic O., Franz Lang B., Vlček Č., Tsaousis A.D., Eliáš M., Doležal P. Analysis of diverse eukaryotes suggests the existence of an ancestral mitochondrial apparatus derived from the bacterial type II secretion system. Nat Commun. 2021 May 19;12(1):2947. doi: 10.1038/s41467-021-23046-7.

Rout S., Oeljeklaus S., Makki A., Tachezy J., Warscheid B., Schneider A. Determinism and contingencies shaped the evolution of mitochondrial protein import. Proceedings of the National Academy of Sciences Feb 2021, 118 (6) e2017774118; DOI: 10.1073/pnas.2017774118

Hierro-Yap C., Šubrtová K., Gahura O., Panicucci B., Dewar C., Chinopoulos Ch., Schnaufer A., Zíková A. Bioenergetic consequences of FoF1–ATP synthase/ATPase deficiency in two life cycle stages of Trypanosoma brucei, Journal of Biological Chemistry, Volume 296, 2021 , ISSN 0021-9258, https://doi.org/10.1016/j.jbc.2021.100357.

Procházková M., Füzik T., Grybchuk D., Luca Falginell F., Podešvová L., Yurchenko V., Vácha R., Plevka P. Capsid structure of Leishmania RNA Virus 1. Journal of Virology. Jan 2021, 95 (3) e01957-20, doi:10.1128/JVI.01957-20

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Gahura O., Hierro Yap C., Zíková A. (2021). Redesigned and reversed: architectural and functional oddities of the trypanosomal ATP synthase. Parasitology. 8:1-41

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Grybchuk, Danyil, Alexei Y. Kostygov, Diego H. Macedo, Jan Votýpka, Julius Lukeš a Vyacheslav Yurchenko. RNA viruses in Blechomonas (Trypanosomatidae) and evolution of Leishmaniavirus. MBIO. 2018, 9(5). DOI: 10.1128/mBio.01932-18.

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Dixit, Sameer a Julius Lukeš. Combinatorial interplay of RNA binding proteins tune levels of mitochondrial mRNA in trypanosomes. RNA. 2018, 24(11), 1594-1606. DOI: 10.1261/rna.066233.118.

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Eva Pyrihová, Alžběta Motyčková, Luboš Voleman, Natalia Wandyszewska, Radovan Fišer, Gabriela Seydlová, Andrew Roger, Martin Kolísko, Pavel Doležal. A single tim translocase in the mitosomes of Giardia intestinalis illustrates convergence of protein import machines in anaerobic eukaryotes. Genome Biology and Evolution, Volume 10, Issue 10. October 2018, Pages 2813–2822, https://doi.org/10.1093/gbe/evy215

Yurchenko V. & Lukeš J. (2018). Parasites and their (endo)symbiotic microbes. Parasitology, 145(10), 1261-1264. DOI:10.1017/S0031182018001257

Jalovecka M., Hajdusek O., Sojka D., Kopacek P. and Malandrin L. (2018) The complexity of piroplasms life cycles. Front. Cell. Infect. Microbiol. 8:248. DOI: 10.3389/fcimb.2018.00248

Peña-Diaz P., Mach J., Kriegová E., Poliak P., Tachezy J., Lukeš J. (2018) Trypanosomal mitochondrial intermediate peptidase does not behave as a classical mitochondrial processing peptidase. PLoS ONE 13(4): e0196474.  https://doi.org/10.1371/journal.pone.0196474

Peña-Diaz P., Lukeš J. Fe–S cluster assembly in the supergroup Excavata. J Biol Inorg Chem 23, 521–541 (2018). https://doi.org/10.1007/s00775-018-1556-6

Harmer J., Yurchenko V., Nenarokova A., Lukeš J., & Ginger M. (2018). Farming, slaving and enslavement: Histories of endosymbioses during kinetoplastid evolution. Parasitology, 145(10), 1311-1323. DOI:10.1017/S0031182018000781

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Spodareva V. V., Grybchuk-Ieremenko A., Losev A., Votýpka J., Lukeš J., Yurchenko V., Kostygov A. Y. Diversity and evolution of anuran trypanosomes: insights from the study of European species. Parasites & Vectors. 2018, 11(1), 447. DOI: 10.1186/s13071-018-3023-1.

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Silva F., Kostygov A., Spodareva V., Butenko A., Tossou R., Lukeš J., Yurchenko V., Alves J. (2018). The reduced genome of Candidatus Kinetoplastibacterium sorsogonicusi, the endosymbiont of Kentomonas sorsogonicus (Trypanosomatidae): Loss of the haem-synthesis pathway. Parasitology, 145(10), 1287-1293. DOI:10.1017/S003118201800046X.

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