Nejvýznamnější výsledky

2018

Schneider B, Boǽíková P, Nečasová I, Čech P, Svozil D, Černý J. A DNA structural alphabet provides new insight into DNA flexibility. Acta Crystallogr D Struct Biol. 2018 Jan 1;74(Pt 1):52-64.

2017

Vališ K, Grobárová V, Hernychová L, Bugáňová M, Kavan D, Kalous M, Černý J, Stodůlková E, Kuzma M, Flieger M, Černý J, Novák P. (2017): Reprogramming of leukemic cell metabolism through the naphthoquinonic compound Quambalarine B. Oncotarget. 2017 Oct 7;8(61):103137-103153.

Schneider B, Božíková P, Čech P, Svozil D, Černý J. A DNA Structural Alphabet Distinguishes Structural Features of DNA Bound to Regulatory Proteins and in the Nucleosome Core Particle. Genes (Basel). 2017 Oct 18;8(10).

Křížová L, Kuchař M, Petroková H, Osička R, Hlavničková M, Pelák O, Černý J, Kalina T, Malý P. p19-targeted ABD-derived protein variants inhibit IL-23 binding and exert suppressive control over IL-23-stimulated expansion of primary human IL-17+ T-cells. Autoimmunity. 2017 Mar;50(2):102-113.

Černý J, Schneider B, Biedermannová L. WatAA: Atlas of Protein Hydration. Exploring synergies between data mining and ab initio calculations. Phys Chem Chem Phys. 2017 Jul 14;19(26):17094-17102.

Rohlenova K, Sachaphibulkij K, Stursa J, Bezawork-Geleta A, Blecha J, Endaya B, Werner L, Cerny J, Zobalova R, Goodwin J, Spacek T, Alizadeh Pesdar E, Yan B, Nguyen MN, Vondrusova M, Sobol M, Jezek P, Hozak P, Truksa J, Rohlena J, Dong LF, Neuzil J: Selective Disruption of Respiratory Supercomplexes as a New Strategy to Suppress Her2(high) Breast Cancer. Antioxid Redox Signal 2017 26(2): 84-103.

2016

Mikulecký P, Zahradník J, Kolenko P, Černý J, Charnavets T, Kolářová L, Nečasová I, Pham PN, Schneider B. Crystal structure of human interferon-γ receptor 2 reveals the structural basis for receptor specificity. Acta Crystallogr D Struct Biol. 2016 Sep;72(Pt 9):1017-25.

Boukalova, S., Stursa, J., Werner, L., Ezrova, Z., Cerny, J., Bezawork-Geleta, A., Pecinova, A., Dong, L., Drahota, Z., Neuzil, J. Mitochondrial Targeting of Metformin Enhances Its Activity against Pancreatic Cancer. Molecular Cancer Therapeutics, 15(12): 2875-2886, 2016. doi: 10.1158/1535-7163.MCT-15-1021. ISSN 1535-7163.

2015

Eva Stodůlková, Ivana Císařová, Miroslav Kolařík, Milada Chudíčková, Petr Novák, Petr Man, Marek Kuzma, Barbora Pavlů, Jan Černý and Miroslav Flieger 2015 Biologically Active Metabolites Produced by the Basidiomycete Quambalaria cyanescens - PloS ONE 10: e0118913

Kluckova, K., Sticha, M., Cerny, J., Mracek, T., Dong, L., Drahota, Z., Gottlieb, E., Neuzil, J., Rohlena, J. Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation. Cell Death & Disease, 6: e1749, 2015. doi: 10.1038/cddis.2015.110. ISSN 2041-4889.

Jiri Cerny, Lada Biedermannova, Pavel Mikulecky, Jiri Zahradnik, Tatsiana Charnavets, Peter Sebo & Bohdan Schneider: Redesigning protein cavities as a strategy for increasing affinity in protein-protein interaction. Interferon-Îł receptor 1 as a model. BioMed Research International 2015: 716945 (2015). doi: 10.1155/2015/716945.

Pierrick Craveur, Agnel P. Joseph, Jeremy Esque, Tarun J. Narwani, Floriane Noel, Nicolas Shinada, Matthieu Goguet, Sylvain Leonard, Pierre Poulain, Olivier Bertrand, Guilhem Faure, Joseph Rebehmed, Amine Ghozlane, Lakshmipuram S. Swapna, Ramachandra M. Bhaskara, Jonathan Barnoud, Stephane Teletchea, Vincent Jallu, Jiri Cerny, Bohdan Schneider, Catherine Etchebest, Narayanaswamy Srinivasan, Jean-Christophe Gelly & Alexandre G. de Brevern: Protein flexibility in the light of structural alphabets. Frontiers in Molecular Biosciences 2: (2015). doi: 10.3389/fmolb.2015.00020.

2014

Milan Kuchar, Lucie Vankova, Hana Petrokova, Jiri Cerny, Radim Osicka, Ondrej Pelak, Hana Sipova, Bohdan Schneider, Jiri Homola, Peter Sebo, Tomas Kalina & Petr Maly: Human interleukin-23 receptor antagonists derived from an albumin-binding domain scaffold inhibit IL-23-dependent ex vivo expansion of IL-17-producing T-cells. Proteins 82, 975-989 (2014). doi:10.1002/prot.24472.

Bohdan Schneider, Jiri Cerny, Daniel Svozil, Petr Cech, Jean-Christophe Gelly & Alexandre G. de Brevern: Bioinformatic analysis of the protein/DNA interface. Nucleic Acids Res. 42, 3381-3394 (2014). doi: 10.1093/nar/gkt1273.

Bohdan Schneider, Jean-Christophe Gelly, Alexandre G. de Brevern & Jiri Cerny: Local dynamics of proteins and DNA evaluated from crystallographic B-factors. Acta Crystallographica D 70: 2413 (2014). doi:10.1107/S1399004714014631.

2013

Pavel Mikulecky, Jiri Cerny, Lada Biedermannova, Hana Petrokova, Milan Kuchar, Jiri Vondrasek, Petr Maly, Peter Sebo & Bohdan Schneider: Increasing affinity of interferon-gamma receptor 1 to interferon-gamma by computer-aided design. BioMed Research International 2013, 12 pages, (2013). doi: 10.1155/2013/752514.

Petr Cech, Jaromir Kukal, Jiri Cerny, Bohdan Schneider & Daniel Svozil: Automatic workflow for the classification of local DNA conformations. BMC Bioinformatics, 14, 205 (2013). doi:10.1186/1471-2105-14-205