Mechanisms of B-cell receptor signal transduction and PI3K/AKT activation in lymphoma

PhD Programme

doc. MUDr. Ondřej Havránek, Ph.D.

doc. MUDr. Ondřej Havránek, Ph.D.

1st Faculty of Medicine of the Charles University

About us

The PhD programme at the BIOCEV Centre facilitates postgraduate studies in the fields of biotechnology and biomedicine. Multiplicity of laboratories with diverse backgrounds have found home in the BIOCEV Centre, belonging namely to the two faculties of the Charles University (1st Faculty of Medicine and Faculty of Science) and the Institute of Biotechnology of Czech Academy of Science (CAS), as well as laboratories of five other CAS institutes - the Institute of Molecular Genetics, the Institute of Microbiology, the Institute of Physiology, the Institute of Experimental Medicine, and the Institute of Macromolecular Chemistry. All these combined create the BIOCEV Centre.

In addition to their research work, the scientific and professional staff of the BIOCEV Centre directly supervise PhD students, of whom over 150 currently work at BIOCEV, and are also involved in the education of both undergraduate and graduate students. In more than 50 laboratories at the BIOCEV Centre, students learn experimental techniques and scientific methodologies under the guidance of experienced experts, which they may apply in a wide range of professional scientific work.

The aim of postgraduate training is not only to deepen knowledge in the chosen field, but also to acquire practical laboratory skills, including planning, conducting and evaluating a scientific experiment, writing scientific publications or student research projects. Similarly important is learning to present one's own scientific results and, last but not least, to develop critical thinking skills.

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If some of the open PhD positions has caught your interest and you have also found agreement with your future supervisor, you need to submit a formal application for PhD studies in Biomedicine (usually by the end of April) and then successfully pass the admission interview in front of the PhD committee (usually during June).

Accepted PhD applicants begin their studies within their chosen Biomedical PhD programme, based either in the Faculty of Science or one of the Charles University's medical faculties. Although the selected PhD programme may slightly differ in its specific requirements, all the incoming PhD students must, in coordination with their supervisor, develop an individual study plan consisting of lectures, courses, and presentations at conferences (either student, national or international level). Similarly, one hones his/her skills in preparation and submission of manuscripts and, last but not least, passing the PhD examination in front of the supervisory committee.

PhD studies are usually four years long (maximum is nine years) and are funded partly by a PhD scholarship from the relevant faculty and partly by an employment contract with the supervisor's department. Successful completion of the PhD programme requires at least one first-author publication in a peer-reviewed journal with an appropriate impact factor (or multiple co-authored publications) and a successful defense of the PhD thesis. However, the specific obligations are described by the respective disciplinary boards that organize the individual fields of study.

Mechanisms of B-cell receptor signal transduction and PI3K/AKT activation in lymphoma

The standard treatment of non-Hodgkin lymphomas (NHL) is still based on a non-specific and highly toxic chemotherapy combinations over 40 years old. Therefore, there is a great need to develop better treatment modalities. Almost all lymphoma cells depend on strong PI3K/AKT signaling cascade activity. We have found that certain lymphomas depend on constitutive activation of PI3K/AKT pathway from B-cell receptor (BCR).

However, specifics of signal transduction via CD19 are not known. Moreover, the source of PI3K/AKT in non BCR dependent tumors are also not known. We would aim to elucidate these mechanisms using well established and reliable lymphoma cell lines by targeted knock out and knock in and CRISPR-based whole genomic screen. Knowing these mechanisms would be important not only for general lymphoma biology, but possibly identify new targets for therapy.

Application form

The first step is to choose the PhD project(s) with the laboratory(-ies) where the PhD candidate would be interested in performing the PhD studies. Next, the candidate fills-in the online Application Form below and submits it. The completed application form will be received by the PhD project supervisor(s), who will then, at their discretion, contact the PhD candidate to discuss the next steps (e.g. online interview, etc.). Upon finding mutual interest, the candidate will then, in agreement with the project supervisor, submit a formal application for a PhD programme to the relevant university board, where the PhD applicant later undergoes admission interview for the PhD studies (usually in June).

The deadline for submitting the application within the BIOCEV Centre is 28th of February 2024, after acceptance to the selected project it is necessary to submit the application for the relevant PhD programme by 30th of April 2024 in the case of faculties of Charles University.

Considered PhD positions ?
Undergraduate education
Graduate (Master’s degree)
Exams & Grades ? Final examination(s) for the Master's degree
Indicate grading system ?
Research experience and skills
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Additional reference
Achievements ?
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Contacts

RNDr. Ladislav Anděra, CSc. RNDr. Ladislav Anděra, CSc.

RNDr.
Ladislav Anděra, CSc.

PhD Program Coordinator

ladislav.andera@ibt.cas.cz
+420325873796
Mgr. Petr Solil, DiS. Mgr. Petr Solil, DiS.

Mgr.
Petr Solil, DiS.

Head of Communications and Spokesperson

petr.solil@ibt.cas.cz
+420325873143
RNDr. Kristýna Pimková, Ph.D. RNDr. Kristýna Pimková, Ph.D.

RNDr.
Kristýna Pimková, Ph.D.

Research Associate & Deputy Head

kristyna.pimkova@lf1.cuni.cz
+420325873026