Postdoctoral Researcher - Antibiotic resistance group in Laboratory for Biology of Secondary Metabolism
Antibiotics that target translation are important tools in the fight against bacterial infections. However, their widespread use has led to the emergence of antibiotic-resistant bacteria that pose a serious threat to public health. ABCF proteins are a recently discovered family of proteins that confer resistance to a wide range of antibiotics that target translation. ABCF proteins function by interacting directly with the ribosome and interfering with antibiotic binding. In addition to resistance determinants acquired through horizontal gene transfer, bacterial genomes harbor putative antibiotic resistance ABCF proteins that may contribute to innate resistance or serve as a reservoir for specialized resistance determinants.