The aim of the project is to understand the interactions of proteins and nucleic acids, discriminate between their specific and nonspecific interactions, and study possible specific modifications of their affinity or specificity.
The project has a close collaboration with the Structural Bioinformatics of Proteins project, the proteins studied are mainly those of the immune system, especially cytokines.
- Explanation of the specificity of interactions of proteins and nucleic acids by analysis of thermodynamic, kinetic, and structural data
- Modification of the interacting partners with the goal to modify specificity and affinity of the complex formation
More information on the project can be found at http://www.structbio.org/bs