Molecular and Cellular Mechanisms of Invasiveness of Tumour Cells

Molecular and Cellular Mechanisms of Invasiveness of Tumour Cells

Doc. RNDr. Jan Brábek, Ph.D.

Doc. RNDr. Jan Brábek, Ph.D. — Project head

About us

This project is focused on functional analysis of mesenchymal and amoeboid invasiveness of tumour cells. The main areas of interests are molecular mechanisms related to structures and turnover of podosomes and invadopodia and the molecular mechanisms of Rho/ROCK pathway activation in amoeboid tumour cells. The research provides potential for development of new anti-metastatic strategies.

Objectives:

  • Determination of the role of integrin-associated Src substrates for mesenchymal tumour cell invasiveness
  • Search for proteins responsible for activation of the Rho/ROCK pathway in amoeboid tumour cells

Official group web page: HERE

News

Publications

2018
2017
2016

Gandalovičová A, Vomastek T, Rosel D, Brábek J.Cell polarity signaling in the plasticity of cancer cell invasiveness. Oncotarget. 2016 May 3;7(18):25022-49. doi: 10.18632/oncotarget.7214. Review.

Jobe NP, Rösel D, Dvořánková B, Kodet O, Lacina L, Mateu R, Smetana K, Brábek J. Simultaneous blocking of IL-6 and IL-8 is sufficient to fully inhibit CAF-induced human melanoma cell invasiveness. Histochem Cell Biol. 2016 Aug;146(2):205-17. doi: 10.1007/s00418-016-1433-8. Epub 2016 Apr 21.

Brábek J, Rosel D, Fernandes M. Pragmatic medicine in solid cancer: a translational alternative to precision medicine. Onco Targets Ther. 2016 Apr 5;9:1839-55. doi: 10.2147/OTT.S103832. eCollection 2016.

2015

Fernandes M, Rosel D, Brábek J. Translation in solid cancer: are size-based response criteria an anachronism? Clin Transl Oncol. 2015 Jan;17(1):1-10. doi: 10.1007/s12094-014-1207-5. Epub 2014 Jul 30.

Pataki CA, Couchman JR, Brábek J. Wnt Signaling Cascades and the Roles of Syndecan Proteoglycans.J Histochem Cytochem. 2015 Jul;63(7):465-80. doi: 10.1369/0022155415586961. Epub 2015 Apr 24. Review.

Vaškovičová K, Szabadosová E, Čermák V, Gandalovičová A, Kasalová L, Rösel D, Brábek J.PKCα promotes the mesenchymal to amoeboid transition and increases cancer cell invasiveness. BMC Cancer. 2015 Apr 29;15:326. doi: 10.1186/s12885-015-1347-1.

2014

Janoštiak R, Brábek J, Auernheimer V, Tatárová Z, Lautscham LA, Dey T, Gemperle J, Merkel R, Goldmann WH, Fabry B, Rösel D. CAS directly interacts with vinculin to control mechanosensing and focal adhesion dynamics. Cell Mol Life Sci. 2014 Feb;71(4):727-44.

Janoštiak R, Pataki AC, Brábek J, Rösel D. Mechanosensors in integrin signaling: The emerging role of p130Cas. Eur J Cell Biol. 2014 Oct;93(10-12): 445-54

2013

Vaškovičová K, Zárský V, Rösel D, Nikolič M, Buccione R, Cvrčková F, Brábek J (2013). Invasive cells in animals and plants: searching for LECA machineries in later eukaryotic life. Biol Direct. 8:8. doi: 10.1186/1745-6150-8-8. (IF 2.720)

Rösel D, Brábek J, Veselý P, Fernandes M. (2013) Drugs for solid cancer: the productivity crisis prompts a rethink. Onco Targets Ther. Jun 26;6:767-77. (IF = 2.073)

Kosla J, Paňková D, Plachý J, Tolde O, Bicanová K, Dvořák M, Rösel D, Brábek J. Metastasis of aggressive amoeboid sarcoma cells is dependent on Rho/ROCK/MLC signaling. Cell Commun Signal. 2013 Jul 30;11(1):51. doi: 10.1186/1478-811X-11-51.