Structural proteins and their complexes

Structural proteins and their complexes

RNDr. Zdeněk Lánský, Ph.D.

RNDr. Zdeněk Lánský, Ph.D. — Project head

The Institute of Biotechnology of the Czech Academy of Sciences

About us

Structural proteins that form cytoskeletal networks form the internal dynamic scaffold of living cells. These networks enable cells to generate mechanical forces, provide their rigidity and drive adaptive changes in their shape and three-dimensional organization. How the individual structural elements of the cytoskeleton mechanically coopeate to produce coherent behavior of the cytoskeletal network during these processes is not understood.

To address these questions, we use genetic manipulations, biochemical and biophysical methods including imaging and manipulation of single molecules. In order to get quantitative insight into the functioning of the networks we accompany our experimental approach with mathematical modeling.

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News

Publications

2019

Siahaan V., Krattenmacher J., Hyman A. A., Diez S., Hernandez-Vega A., Lansky Z., Braun M. Kinetically distinct phases of tau on microtubules regulate kinesin motors and severing enzymes. Nature Cell Biology, 2019, 21, 1086–1092.

 

Schmidt-Cernohorska M, Zhernov I, Steib E, Le Guennec M, Achek R, Borgers S, Demurtas D, Mouawad L, Lansky Z, Hamel V, Guichard P. Flagellar microtubule doublet assembly in vitro reveals a regulatory role of tubulin C-terminal tails.
Science, 2019, 363(6424):285-288.

2018

Lüdecke, A., Seidel, A.M., Braun, M., Lansky, Z., Diez, S. Diffusive tail anchorage determines velocity and force produced by kinesin-14 between crosslinked microtubules. Nature Communications 2018, 9(1):2214.