Structure and Function of Cells in Their Normal State and in Pathology – Integrative Biology and Pathology

Structure and Function of Cells in Their Normal State and in Pathology – Integrative Biology and Pathology

MUDr. Zdeněk Kostrouch, CSc.

MUDr. Zdeněk Kostrouch, CSc. — Project head

1st Faculty of Medicine of the Charles University

About us

The aim of the research group is to use invertebrate model systems and advanced informatics for the identification and analysis of regulatory cascades that determine normal development and metabolism of Metazoan organisms and play critical roles in human diseases. The projects focus on regulatory mechanisms involving nuclear receptors and proteins that transmit and/or modulate their function.

Model systems used for this research include nematodes (Caenorhabditis elegans and other Rhabditidae), flatworms (Schmidtea mediterranea) and Diploblastic species (cubomedusan jellyfish Tripedalia cystophora, Aurelia aurita, corals, sea anemones, Porifera and Placozoa). Parallel to model organisms, the research is conducted on mammalian cell cultures and on human samples.

 

Research Objectives:

  • The identification of conserved regulatory mechanisms including nuclear receptors and proteins that transmit or modulate their function.
  • The analysis of the parallel (orthologous) mechanisms in mammalian cells and human tissues, including cancers.

 

Projects:

  1. Regulation of metabolism and development at the base of Deuterostome evolution.
  2. Regulatory networks of nuclear receptors in nematodes.
  3. Nuclear receptors in human cancers.
  4. Interactors of regulatory pathways involving nuclear receptors – regulatory RNAs, endocrine disruptors and functionally shared proteins.

 

Further details about research group  at https://biocev.lf1.cuni.cz/kostrouchlab

 

 

News

Publications

2019

Kaššák F, Hána V, Saudek V, Kostrouchová M. Novel Mutation (T273R) in Thyroid Hormone Receptor β Gene Provides Further Insight into Cryptic Negative Regulation by Thyroid Hormone. Folia Biol (Praha). 2017;63(2):60-66.

Novotný JP, Chughtai AA, Kostrouchová M, Kostrouchová V, Kostrouch D, Kaššák F, Kaňa R, Schierwater B, Kostrouchová M, Kostrouch Z. Trichoplax adhaerens reveals a network of nuclear receptors sensitive to 9-cis-retinoic acid at the base of metazoan evolution. PeerJ. 2017 Sep 29;5:e3789. doi: 10.7717/peerj.3789. eCollection 2017.

2018

Kollárová J, Kostrouchová M, Benda A, Kostrouchová M. ALKB-8, a 2-Oxoglutarate-Dependent Dioxygenase and S-Adenosine Methionine-Dependent Methyltransferase Modulates Metabolic Events Linked to Lysosome-Related Organelles and Aging in C. elegans. Folia Biol (Praha). 2018;64(2):46-58. (IF 1.044)

Kostrouchová M, Kostrouchová V, Yilma P, Benda A, Mandys V, Kostrouchová M.
Valproic Acid Decreases the Nuclear Localization of MDT-28, the Nematode
Orthologue of MED28. Folia Biol (Praha). 2018;64(1):1-9. (IF 1.044)

2017

Kaššák F, Hána V, Saudek V, Kostrouchová M. Novel Mutation (T273R) in Thyroid
Hormone Receptor β Gene Provides Further Insight into Cryptic Negative Regulation
by Thyroid Hormone. Folia Biol (Praha). 2017;63(2):60-66. (IF 0.833)

Novotný JP, Chughtai AA, Kostrouchová M, Kostrouchová V, Kostrouch D, Kaššák F, Kaňa R, Schierwater B, Kostrouchová M, Kostrouch Z. Trichoplax adhaerens reveals a network of nuclear receptors sensitive to 9-cis-retinoic acid at the base of metazoan evolution. PeerJ. 2017 Sep 29;5:e3789. doi: 10.7717/peerj.3789. eCollection 2017. (IF 2.177)

Kostrouchová M, Kostrouch D, Chughtai AA, Kaššák F, Novotný JP, Kostrouchová V, Benda A, Krause MW, Saudek V, Kostrouchová M, Kostrouch Z. The nematode homologue of Mediator complex subunit 28, F28F8.5, is a critical regulator of C. elegans development. PeerJ. 2017 Jun 6;5:e3390. doi: 10.7717/peerj.3390. eCollection 2017. (IF 2.177)

Team

MUDr. Zdeněk Kostrouch, CSc. MUDr. Zdeněk Kostrouch, CSc.

MUDr.
Zdeněk Kostrouch, CSc.

Head of Group Structure and Function of Cells in Their Normal State and in Pathology - Integrative Biology and Pathology (5.2.4.); Head of Laboratory of Molecular Pathology (1st Faculty of Medicine, Charles University)

zdenek.kostrouch@lf1.cuni.cz
+420325873020
MUDr. Marta Kostrouchová, CSc. MUDr. Marta Kostrouchová, CSc.

MUDr.
Marta Kostrouchová, CSc.

Principal Investigator Structure and Function of Cells in Their Normal State and in Pathology - Integrative Biology and Pathology (5.2.4.); 017Head of Laboratory of Molecular Biology and Genetics (1st Faculty of Medicine, Charles University)

marta.kostrouchova@lf1.cuni.cz
+420325873017, +420325873019
Ing. Petr Yilma, Ph.D. Ing. Petr Yilma, Ph.D.

Ing.
Petr Yilma, Ph.D.

Research Fellow

petr.yilma@lf1.cuni.cz
+420325873019