Prof. MUDr. Tomáš Stopka, Ph.D.

Prof. MUDr. Tomáš Stopka, Ph.D.

Head of Laboratory of Haematooncology and Stem Cells

Hematologist, graduate of the 1st Faculty of Medicine, PhD in genetics and molecular biology, professor of pathophysiology.

In the early years of his scientific activity he worked at the University of Alabama in Birmingham in 1996-1998 under the supervision of Prof. J.T. Prchal and then from 2001-2005 at the Albert Einstein College of Medicine in New York in the laboratory of Prof. A.I. Skoultchi.

His area of interest includes molecular and clinical hematology of myeloid malignancies. His research interests include tumor epigenetics, therapeutic resistance and hematopoietic cell differentiation. He also complements his scientific and pedagogical activities by his work as a consultant and editor.

Since 2016, he has been the head of the Institute of BIOCEV, First Faculty of Medicine, Charles University, where his research group is also based.

More information to be found at : STOPKA_LAB and PUBLONS

Recent publications

2020

Zikmund T, Paszekova H, Kokavec J, Kerbs P, Thakur S, Turkova T, Tauchmanova P, Greif PA, Stopka T. Loss of ISWI ATPase SMARCA5 (SNF2H) in Acute Myeloid Leukemia Cells Inhibits Proliferation and Chromatid Cohesion. Int J Mol Sci. 2020;21(6):E2073. Published 2020 Mar 18. doi:10.3390/ijms21062073. (IF 4.183)

Zhang C, Chen Z, Yin Q, Fu X, Li Y, Stopka T, Skoultchi A, Zhang Y. The chromatin remodeler Snf2h is essential for oocyte meiotic cell cycle progression. Genes Dev. 2020;34(3-4):166–178. doi:10.1101/gad.331157.119. (IF 8.998)

Pribyl M, Hubackova S, Moudra A, Vancurova M, Polackova H, Stopka T, Jonasova A, Bokorova R, Fuchs O, Stritesky J, Salovska B, Bartek J, Hodny Z. Aberrantly elevated suprabasin in the bone marrow as a candidate biomarker of advanced disease state in myelodysplastic syndromes. Mol Oncol. 2020 Oct;14(10):2403-2419. doi: 10.1002/1878-0261.12768. (IF 6.574)

Minarik L, Vargova K, Dusilkova N, Kulvait V, Jonasova A, Kodet O, Stopka T. Hereditary Haemorrhagic Telangiectasia (HHT) Marked by ACVRL1C1120T Variant Displays Hypopigmented Naevi and Frequent Bleeding Episodes if CYP2C9 Co-Mutated: Clinical Notes & Rationale of Patient Registry. Folia Biol (Praha). 2020;66(1):1-6. (IF 1.073)

2019

Zikmund T, Kokavec J, Turkova T, Savvulidi F, Paszekova H, Vodenkova S,
Sedlacek R, Skoultchi AI, Stopka T. ISWI ATPase Smarca5 Regulates Differentiation
of Thymocytes Undergoing β-Selection. J Immunol. 2019 Jun 15;202(12):3434-3446.
doi: 10.4049/jimmunol.1801684.

Skalicka P, Dudakova L, Palos M, Huna LJ, Evans CJ, Mahelkova G, Meliska M, Stopka T, Tuft S, Liskova P. Paraproteinemic keratopathy associated with monoclonal gammopathy of undetermined significance (MGUS): clinical findings in twelve patients including recurrence after keratoplasty. Acta Ophthalmol. 2019 May 2. doi: 10.1111/aos.14123. (IF 3.032)

Minarik L, Zemanova Z, Kulvait V, Dluhosova M, Jonasova A and Stopka T. Azacitidine Switch to Lenalidomide Eradicated the TP53/ CDKN2A Co-Mutated Clone and Induced Long-Term Erythroid Response in Del(5q) MDS. Ann Hematol Oncol. 2019; 6(1): 0000. (IF 2.219)

Stopka T, Minarik L, Kulvait V, Pesta M, Schaffartzikova A, Kislik G, Dusilkova N, Zemanova Z, Jonasova A. Randomizovaná otevřená akademická studie: srovnání standardního podání azacytidinu oproti azacytidinu s preinkubací G-CSF u myelodysplastického syndromu vyššího rizika – interim analýza. Myelodysplastic Syndrome NEWS. Ročník 7 / číslo 2 / listopad 2019.

2018

Sochor M, Basova P, Pesta M, Dusilkova N, Bartos J, Burda P, Pospisil V, Stopka T. Oncogenic microRNAs: miR-155, miR-19a, miR-181b, and miR-24 enable monitoring of early breast cancer in serum. BMC Cancer. 2014 Jun 18;14:448. (IF 3.362)

2017

Vargova K, Pesta M, Obrtlíkova P, Dusilkova N, Minarik L, Vargova J, Berkova A, Zemanova Z, Michalova K, Spacek M, Trneny M and Stopka T. MiR-155/miR-150 network regulates progression through the disease phases of chronic lymphocytic leukemia. Blood Cancer J. 2017 Jul 21;7(7):e585. doi: 10.1038/bcj.2017.63. (IF: 6.126)

Stopka T. Využití detekce somatických mutací pro pacienty s cytopenií nejasného významu a u myelodysplastického syndromu.  Myelodysplastic Syndrome NEWS. Ročník 5 / Číslo 1 / květen 2017

Huskova H, Ardin M, Weninger A, Vargova K, Barrin S, Villar S, Olivier M, Stopka T, Herceg Z, Hollstein M, Zavadil J, Korenjak M. Modeling cancer driver events in vitro using barrier bypass-clonal expansion assays and massively parallel sequencing. Oncogene. 2017 Jul 10. doi: 10.1038/onc.2017.215. (IF: 7.519)

Kokavec J, Zikmund T, Savvulidi F, Kulvait V, Edelmann W, Skoultchi AI, Stopka T. The ISWI ATPase Smarca5 (Snf2h) Is Required for Proliferation and Differentiation of Hematopoietic Stem and Progenitor Cells. Stem Cells. 2017 Jun;35(6):1614-1623. doi: 10.1002/stem.2604. (IF: 5.599)

2016

He S, Limi S, McGreal RS, Xie Q, Brennan LA, Kantorow WL, Kokavec J, Majumdar R, Hou H Jr, Edelmann W, Liu W, Ashery-Padan R, Zavadil J, Kantorow M, Skoultchi AI, Stopka T, Cvekl A. Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation. Development. 2016 Jun 1;143(11):1937-47. doi: 10.1242/dev.135285..

2014

Basova P, Pospisil V, Savvulidi F, Burda P, Vargova K, Stanek L, Dluhosova M, Kuzmova E, Jonasova A, Steidl U, Laslo P, Stopka T. Aggressive acute myeloid leukemia in PU.1/p53 double-mutant mice. Oncogene. 2014 Sep 25;33(39):4735-45. doi: 10.1038/onc.2013.414. (IF: 8.459)

Alvarez-Saavedra M, De Repentigny Y, Lagali PS, Raghu Ram EV, Yan K, Hashem E, Ivanochko D, Huh MS, Yang D, Mears AJ, Todd MA, Corcoran CP, Bassett EA, Tokarew NJ, Kokavec J, Majumder R, Ioshikhes I, Wallace VA, Kothary R, Meshorer E, Stopka T, Skoultchi AI, Picketts DJ. Snf2h-mediated chromatin organization and histone H1 dynamics govern cerebellar morphogenesis and neural maturation. Nat Commun. 2014 Jun 20;5:4181 (IF:11.470)

Dluhosova M, Curik N, Vargova J, Jonasova A, Zikmund T,Stopka T. Epigenetic control of SPI1 gene by CTCF and ISWI ATPase SMARCA5. PLoS One. 2014 Feb 3;9(2):e87448.

A. Laslo P* and Stopka T*. Transcriptional and epigenetic regulation in the development of myeloid cells: normal and diseased myelopoiesis. Book Chapter, 2014. “Epigenetics and Human Health” publisher: Springer*Equal Corresponding Author, in press 2013, issued Feb2014

2013

Machova Polakova K, Koblihova J, Stopka T. Role of epigenetics in chronic myeloid leukemia. Curr Hematol Malig Rep. 2013 Mar;8(1):28-36. doi: 10.1007/s11899-012-0152-z. (IF: 2.3)