prof. MUDr. Ladislav Vyklický, DrSc.

prof. MUDr. Ladislav Vyklický, DrSc.

The Institute of Physiology of the Czech Academy of Sciences
Head of Group Structure and Function of Membrane Receptors

ladislav.vyklicky@fgu.cas.cz
+420325873502

The N-methyl-D-aspartate (NMDA) subtype of glutamate receptors mediates the fast excitatory transmission at central synapses; however, their excessive activation may result in excitotoxic neurodegeneration.

We are focused on how NMDAR functions are regulated by neurosteroids that modulate their activity, The results of our study help us to elucidate the role of NMDARs in the pathogenesis of neurological and psychiatric diseases and to search for effective ways of treatment.

Ladisalav Vyklický in PubMed

Recent publications

2012

Borovská J, Vyklický V, Štastná E, Kapras V, Slavíková B, Horák M, Chodounská H, Vyklický L, Jr.: Access of inhibitory neurosteroids to the NMDA receptor. British Journal of Pharmacology 2012; 166: 1069-1083.

Černý I, Buděšínský M, Pouzar V, Vyklický V, Krausová B, Vyklický L, Jr.: Neuroactive steroids with perfluorobenzoyl group. Steroids 2012; 77: 1233-41

Palma-Cerda F, Auger C, Crawford DJ, Hodgson AC, Reynolds SJ, Cowell JK, Swift KA, Cais O, Vyklicky L, Corrie JE, Ogden D: New caged neurotransmitter analogs selective for glutamate receptor sub-types based on methoxynitroindoline and nitrophenylethoxycarbonyl caging groups. Neuropharmacology 2012; 63: 624-634.

Valeš K, Rambousek L, Holubová K, Svoboda J, Bubeníková-Valešová V, Chodounská H, Vyklický L, Stuchlík A: 3alpha5beta-Pregnanolone glutamate, a use-dependent NMDA antagonist, reversed spatial learning deficit in an animal model of schizophrenia. Behavioural Brain Research 2012; 235: 82-88.

2011

Kořínek M, Kapras V, Vyklický V, Adamusová E, Borovská J, Valeš K, Stuchlík A, Horák M, Chodounská H, Vyklický L, Jr.: Neurosteroid modulation of N-methyl-D-aspartate receptors: molecular mechanism and behavioral effects. Steroids 2011; 76: 1409-1418.

Rambousek L, Bubeníková-Valešová V, Kačer P, Syslová K, Kenney J, Holubová K, Najmanová V, Zach P, Svoboda J, Stuchlík A, Chodounská H, Kapras V, Adamusová E, Borovská J, Vyklický L, Valeš K: Cellular and behavioural effects of a new steroidal inhibitor of the N-methyl-d-aspartate receptor 3alpha5beta-pregnanolone glutamate. Neuropharmacology 2011; 61: 61-68.