Recent publications

2017

Dong, L. F., Kovarova, J., Bajzikova, M., Bezawork-Geleta, A., Svec, D., Endaya, B., Sachaphibulkij, K., Coelho, A. R., Sebkova, N., Ruzickova, A., Tan, A. S., Kluckova, K., Judasova, K., Zamecnikova, K., Rychtarcikova, Z., Gopalan, V., Sobol, M., Yan, B., Pattnaik, B., Bhatraju, N., Truksa, J., Stopka, P., Hozak, P., Lam, A., Sedlacek, R., Oliveira, P. J., Kubista, M., Agrawal, A., Dvorakova-Hortova, K., Rohlena, J., Berridge, M. V., Neuzil, J. Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells. eLife, 6: e22187, 2017. doi: 10.7554/eLife.22187. ISSN 2050-084X.

Rohlenova, K., Sachaphibulkij, K., Stursa, J., Bezawork-Geleta, A., Blecha, J., Endaya, B., Werner, L., Cerny, J., Zobalova, R., Goodwin, J., Spacek, T., Alisadeh, E., Yan, B., Nguyen, M., Vondrusova, M., Sobol, M., Jezek, P., Hozak, P., Truksa, J., Rohlena, J., Dong, L., Neuzil, J. Selective disruption of respiratory supercomplexes as a new strategy to suppress Her2-high breast cancer. Antioxidants & Redox Signaling, 26(2): 84-103, 2017. doi: 10.1089/ars.2016.6677. ISSN 1557-7716.

Rychtarcikova, Z., Lettlova, S., Tomkova, V., Korenkova, V., Langerova, L., Simonova, E., Zjablovskaja, P., Alberich-Jorda, M., Neuzil, J., Truksa, J. Tumor-initiating cells of breast and prostate origin show alterations in the expression of genes related to iron metabolism. Oncotarget, 8: 6376-6398, 2017. doi: 10.18632/oncotarget.14093. ISSN: 1949-2553.

Rohlenova K, Sachaphibulkij K, Stursa J, Bezawork-Geleta A, Blecha J, Endaya B, Werner L, Cerny J, Zobalova R, Goodwin J, Spacek T, Alizadeh Pesdar E, Yan B, Nguyen MN, Vondrusova M, Sobol M, Jezek P, Hozak P, Truksa J, Rohlena J, Dong LF, Neuzil J: Selective Disruption of Respiratory Supercomplexes as a New Strategy to Suppress Her2(high) Breast Cancer. Antioxid Redox Signal 2017 26(2): 84-103.

2016

Tomasetti, M., Monaco, F., Manzella, N., Rohlena, J., Rohlenova, K., Staffolani, S., Gaetani, S., Ciarapica, V., Amati, M., Bracci, M., Valentino, M., Goodwin, J., Nguyen, M., Truksa, J., Sobol, M., Hozak, P., Dong, L. F., Santarelli, L., Neuzil, J. MicroRNA-126 induces autophagy by altering cell metabolism in malignant mesothelioma. Oncotarget, 7(24): 36338-36352, 2016. doi: 10.18632/oncotarget.8916. ISSN 1949-2553.

Tomasetti M, Monaco F, Manzella N, Rohlena J, Rohlenova K, Staffolani S, Gaetani S, Ciarapica V, Amati M, Bracci M, Valentino M, Goodwin J, Nguyen M, Truksa J, Sobol M, Hozak P, Dong LF, Santarelli L, Neuzil J: MicroRNA-126 induces autophagy by altering cell metabolism in malignant mesothelioma. Oncotarget 2016 7(24): 36338-36352.

2015

Tan, A. S., Baty, J. W., Dong, L., Bezawork-Geleta, A., Endaya, B., Goodwin, J., Bajzikova, M., Kovarova, J., Peterka, M., Yan, B., Pesdar, E. A., Sobol, M., Filimonenko, A., Stuart, S., Vondrusova, M., Kluckova, K., Sachaphibulkij, K., Rohlena, J., Hozak, P., Truksa, J., Eccles, D., Haupt, L. M., Griffiths, L. R., Neuzil, J., Berridge, M. V. Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA. Cell Metabolism, 21(1): 81-94, 2015. doi: 10.1016/j.cmet.2014.12.003. ISSN 1550-4131.

Truksa, J., Dong, L., Rohlena, J., Stursa, J., Vondrusova, M., Goodwin, J., Nguyen, M., Kluckova, K., Rychtarcikova, Z., Lettlova, S., Spacilova, J., Stapelberg, M., Zoratti, M., Neuzil, J. Mitochondrially targeted vitamin E succinate modulates expression of mitochondrial DNA transcripts and mitochondrial biogenesis. Antioxidants & Redox Signaling, 22(11): 883-900, 2015. doi: 10.1089/ars.2013.5594. ISSN 1523-0864.

Vondrusova, M., Bezawork-Geleta, A., Sachaphibulkij, K., Truksa, J., Neuzil, J. The effect of mitochondrially targeted anticancer agents on mitochondrial (super)complexes. Mitochondrial Medicine, 1265: 195-208, 2015. doi: 10.1007/978-1-4939-2288-8_15. ISSN 1064-3745.

Tan AS, Baty JW, Dong LF, Bezawork-Geleta A, Endaya B, Goodwin J, Bajzikova M, Kovarova J, Peterka M, Yan B, Pesdar EA, Sobol M, Filimonenko A, Stuart S, Vondrusova M, Kluckova K, Sachaphibulkij K, Rohlena J, Hozak P, Truksa J, Eccles D, Haupt LM, Griffiths LR, Neuzil J, Berridge MV: Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA. Cell Metab 2015 21(1): 81-94.

2014

Kovarova, J., Bajzikova, M., Vondrusova, M., Stursa, J., Goodwin, J., Nguyen, M., Zobalova, R., Pesdar, E. A., Truksa, J., Tomasetti, M., Dong, L. F., Neuzil, J. Mitochondrial targeting of alpha-tocopheryl succinate enhances its anti-mesothelioma efficacy. Redox Reports, 19(1): 16-25, 2014. doi: 10.1179/1351000213Y.0000000064.

Stapelberg, M., Zobalova, R., Nguyen, M. N., Walker, T., Stantic, M., Goodwin, J., Pasdar, E. A., Thai, T., Prokopova, K., Yan, B., Hall, S., de Pennington, N., Thomas, S. R., Grant, G., Stursa, J., Bajzikova, M., Meedeniya, A. C. B., Truksa, J., Ralph, S. J., Ansorge, O., Dong, L. F., Neuzil, J. Indoleamine-2,3-dioxygenase elevated in tumor-initiating cells is suppressed by mitocans. Free Radical Biology and Medicine, 67: 41-50, 2014. doi: 10.1016/j.freeradbiomed.2013.10.003.

Tomasetti, M., Nocchi, L., Staffolani, S., Manzella, N., Amati, M., Goodwin, J., Kluckova, K., Nguyen, M., Strafella, E., Bajzikova, M., Peterka, M., Lettlova, S., Truksa, J., Lee, W., Dong, L. F., Santarelli, L., Neuzil, J. MicroRNA-126 Suppresses Mesothelioma Malignancy by Targeting IRS1 and Interfering with the Mitochondrial Function. Antioxidants & Redox Signaling, 21(15): 2109-2125, 2014. doi: 10.1089/ars.2013.5215. ISSN 1523-0864.

2013

Neuzil, J., Dong, L. F., Rohlena, J., Truksa, J., Ralph, S. J. Classification of mitocans, anti-cancer drugs acting on mitochondria. Mitochondrion, 13(3): 199-208, 2013. doi: 10.1016/j.mito.2012.07.112. ISSN 1567-7249.

2011

Dong LF, Jameson VJA, Tilly D, Cerny J, Mahdavian E, Marín-Hernández A, Hernández-Esquivel L, Rodríguez-Enríquez S, Stursa J, Witting PK, Stantic B, Rohlena J, Truksa J, Kluckova K, Dyason JC, Ledvina M, Salvatore BA, Moreno-Sánchez R, Coster MJ, Ralph SJ, Smith RAJ, Neuzil J (2011) Mitochondrial targeting of vitamin E succinate enhances its pro-apoptotic and anti-cancer activity via mitochondrial complex II. J Biol Chem 286, 3717-3728.

Valis K, Prochazka L, Boura E, Chladova M, Obsil T, Rohlena J, Truksa J, Dong LF, Ralph SJ, Neuzil J (2011) Hippo/Mst1 stimulates transcription of NOXA in a FoxO1-dependent manner. Cancer Res 71, 946-954.