Mgr. Daniel Rozbeský, Ph.D.

Mgr. Daniel Rozbeský, Ph.D.

The Faculty of Science of the Charles University
Principal Investigator

Daniel is a Research Fellow at Charles University in Prague. His research is primarily focused on the structural biology of signalling molecules and cell surface receptors that play central roles in neurobiology and human disease.

Daniel received his PhD in Biochemistry from Charles University in 2013, and then joined the lab of Yvonne Jones at the University of Oxford for his postdoctoral training (2013-2020). In 2020, he returned to Charles University to set up his lab in the Department of Cell Biology at the BIOCEV research institute.

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Recent publications


Mehta V, Pang KL, Rozbesky D, Nather K, Keen A, Lachowski D, Kong Y, Karia D, Ameismeier M, Huang J, Fang Y, Del Rio Hernandez A, Reader JS, Jones EY, Tzima E (2020). The guidance receptor Plexin D1 moonlights as an endothelial mechanosensor. Nature. 578: 290-295

Rozbesky D, Monistrol J, Jain V, Hillier J, Padilla-Parra S, Jones EY (2020). Drosophila OTK is a glycosaminoglycan-binding protein with high conformational flexibility. Structure. 28: 507-515.

Rozbesky D, Verhagen MG, Karia D, Nagy GN, Alvarez L, Harlos K, Padilla-Parra S, Pasterkamp RJ, Jones EY. Structural basis of semaphorin-plexin cis interaction. EMBO J. 39: e102926


Rozbesky D, Robinson RA, Jain V, Renner M, Malinauskas T, Harlos K, Siebold C, Jones EY (2019). Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning. Nat Commun. 10: 3691-3703.


Walters LC, Harlos K, Brackenridge S, Rozbesky D, Barrett J, Jain V, O’Callaghan C, Borrow P, Toebes M, Hansen SG, Sacha J, Abdulhaqq S, Greene JM, Fruh K, Marshall E, Picker LJ, Jones EY, McMichael AJ, Gillespie GM (2018) Pathogen-derived HLA bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding. Nat Commun. 9: 3137-3150