RNDr. Cyril Bařinka, Ph.D.

RNDr. Cyril Bařinka, Ph.D.

The Institute of Biotechnology of the Czech Academy of Sciences
Head of Group Molecular Interactions of Anti-cancer Drugs

Cyril graduated in biochemistry at Charles University, Prague, and did his PhD at the Institute of Organic chemistry & Biochemistry, Prague, in Jan Konvalinka lab.

He spent five year at the National Cancer Institute at Frederick, MD, USA in the Jacek Lubkowski lab, focusing on protein crystallography. In 2010, he came back to Prague, the Czech Republic, where he established the Laboratory of Structural Biology at the Institute of Biotechnology.


Group Profile (Home Institution): Laboratory of Structural Biology (IBT ASCR)

Cyril Bařinka in Pubmed

Recent publications


Lv, W., Zhang, G., Barinka, C., Eubanks J. H., Kozikowski, A. P. Design and Synthesis of Mercaptoacetamides as Potent, Selective, and Brain Permeable Histone Deacetylase 6 Inhibitors. ACS Medicinal Chemistry Letters, 8(5): 510-515, 2017. doi: 10.1021/acsmedchemlett.7b00012. ISSN 1948-5875.


Alquicer G, Sedlák D, ByunY,Pavlíček J, StathisM, Rojas C, Slusher B, Pomper MG, Bartůněk P, and Bařinka C.: Development of a high-throughput fluorescence polarization assay to identify novel ligands of glutamate carboxypeptidase II. J Biomol Screening 2012, 17:1030-1040.


Plechanovova A, Byun Y, Alquicer G, Skultetyova L, Mlcochova P, Nemcova A, Kim HJ, Navratil M, Mease R, Lubkowski J, Pomper MG, Konvalinka J, Rulisek L, Barinka C.: Novel substrate-based inhibitors of human glutamate carboxypeptidase II with enhanced lipophilicity. J Med Chem 2011, 54:7535-7546.


Zhang AX, Murelli RP, Barinka C, Michel J, Cocleaza A, Jorgensen WL, Lubkowski J, Spiegel DA: A remote arene-binding site on prostate specific membrane antigen revealed by antibody-recruiting small molecules. J Am Chem Soc 2010, 132:12711-12716.