Postdoctoral Researcher - Biofilm research in Laboratory of biology of yeast colonies
Understanding the conditions and factors (including regulators) that are important for microbial cell adhesion and biofilm formation on differently modified solid surfaces (metals, plastics).
Biofilms are complex, highly organized three-dimensional (3D) structures formed by various microbes (bacteria, yeasts and others). Due to their enormous resistance to external influences, they represent a very dangerous contamination of surfaces in biomedicine (e.g. on catheters, implants, prostheses, etc.) as well as in industry (e.g. in water reservoirs and other pipelines), where they can cause serious diseases or block the functionality of the respective devices. Biofilm life-cycle includes cell adhesion to solid surface, followed by a formation of a 3D structure and maturation of the complex biofilm, which is highly resistant to external influences (including drugs). Our team's long-term research focuses on investigating the molecular and cellular mechanisms involved in the development and differentiation of spatially organized yeast structures (biofilms and colonies).
In the project, different variants of functional micro- and nanostructured surfaces of relevant materials produced by laser will be tested for microbial adhesion and subsequent biofilm formation. Selected variants will then be examined for molecular mechanisms of the relationship between the strength of cell adhesion (a key parameter for biofilm formation) and the structure of the mature biofilm.
Web pages of the research group:
- PhD degree in microbiology, molecular biology or a related field
- Experience in baterial and/or yeast genetics
- Experience in bacterial strain constructions is an advantage
- Excellent communication skills in English
- Strong publication experience
- Conduct research on microbial cell adhesion experiments using specifically modified materials, construction of recombinant bacterial/yeast strains for testing, development of reproducible assays for quantification of adhesion of specific bacteria, analysis of biofilms by OMICs approaches.
- Collaborate with other researchers involved in other aspects of the project
- Publish research results in high impact scientific journals
- Duration: ~2 years, renewable based on performance
- Salary: Competitive salary commensurate with experience