Doc. Dr. Radislav Sedláček, Ph.D.

Doc. Dr. Radislav Sedláček, Ph.D.

Member of the Board, Head of Program Functional Genomics, Head of Czech Centre for Phenogenomics, Head of Group - Phenogenomics: Systematic phenotypic analysis of mice and rat mutant models for the annotation of gene function

His scientific career has been devoted to understanding the function of
metalloproteinases, especially their role in vivo using mouse models.

Radek Sedláček was recruited to IMG to establish transgenic technology and infrastructure for generation, archiving and distribution of mouse models.

He supports a number of scientific groups in the Czech Republic and European countries with his expertise in the field of generation of transgenic mouse models, he  proposed, designed, and is managing the Czech Centre for Phenogenomics (CCP) that is integral part of the Programme on Functional Genomics;

Besides being a member of the Board of Directors of EMMA and INFRAFRONTIER, he also represents the Czech Republic in the Thematic Working Group on Biological and Medical sciences (BMS) under ESFRI (European Strategy Forum on Research Infrastructures) and coordinates BMS infrastructures in the Czech Republic. R. Sedláček holds also broad interaction with national and international scientific partners in the field of mouse disease models and functional genomics. These expertise and interactions link together the groups of the research programme and create a cooperation base for external partners.

 

R. Sedláček in Media

Czech scientists make mice cells glow different colors to advance genetic research (Deutsche Welle)

 

Group Profile (Home Institution): www.phenogenomics.cz

 

Publications:

Recent publications (in Pubmed)

 

More info in attached CV

 

Recent publications

2018

Rozman J, Rathkolb B, Oestereicher MA, Schütt C, Ravindranath AC, Leuchtenberger S, Sharma S, Kistler M, Willershäuser M, Brommage R, Meehan TF, Mason J, Haselimashhadi H; IMPC Consortium, Hough T, Mallon AM, Wells S, Santos L, Lelliott CJ, White JK, Sorg T, Champy MF, Bower LR, Reynolds CL, Flenniken AM, Murray SA, Nutter LMJ, Svenson KL, West D, Tocchini-Valentini GP, Beaudet AL, Bosch F, Braun RB, Dobbie MS, Gao X, Herault Y, Moshiri A, Moore BA, Kent Lloyd KC, McKerlie C, Masuya H, Tanaka N, Flicek P, Parkinson HE, Sedlacek R, Seong JK, Wang CL, Moore M, Brown SD, Tschöp MH, Wurst W, Klingenspor M, Wolf E, Beckers J, Machicao F, Peter A, Staiger H, Häring HU, Grallert H, Campillos M, Maier H, Fuchs H, Gailus-Durner V, Werner T, Hrabe de Angelis M. Identification of genetic elements in metabolism by high-throughput mouse phenotyping. Nat Commun. 2018 Jan 18;9(1):288. doi: 10.1038/s41467-017-01995-2.

2017

Mikyskova R, Indrova M, Stepanek I, Kanchev I, Bieblova J, Vosahlikova S, Moserova I, Truxova I, Fucikova J, Bartunkova J, Spisek R, Sedlacek R, Reinis M. Dendritic cells pulsed with tumor cells killed by high hydrostatic pressure inhibit prostate tumor growth in TRAMP mice. Oncoimmunology. 2017;6(12):e1362528.

Bhargava S, Cox B, Polydorou C, Gresakova V, Korinek V, Strnad H, Sedlacek R, Epp TA, Chawengsaksophak K. The epigenetic modifier Fam208a is required to maintain epiblast cell fitness. Sci Rep. 2017 Aug 24;7(1):9322. doi: 10.1038/s41598-017-09490-w.

Jirouskova M, Nepomucka K, Oyman-Eyrilmez G, Kalendova A, Havelkova H, Sarnova L, Chalupsky K, Schuster B, Benada O, Miksatkova P, Kuchar M, Fabian O, Sedlacek R, Wiche G, Gregor M. Plectin Controls Biliary Tree Architecture and Stability in Cholestasis. Hepatol. J Hepatol. 2017 Dec 19. pii: S0168-8278(17)32495-9.

Skopova K, Tomalova B, Kanchev I, Rossmann P, Svedova M, Adkins I, Bibova I, Tomala J, Masin J, Guiso N, Osicka R, Sedlacek R, Kovar M, Sebo P. cAMP-elevating capacity of the adenylate cyclase toxin-hemolysin is sufficient for lung infection but not for full virulence of Bordetella pertussis. Infect Immun. 2017 Apr 10. pii: IAI.00937-16. doi: 10.1128/IAI.00937-16.

Zbodakova O, Chalupsky K, Tureckova J, Sedlacek R. Metalloproteinases in liver fibrosis: current insights. Metalloproteinases In Medicine 2017:4 25–35 review, (in press)

Wald T, Spoutil F, Osickova A, Prochazkova M, Benada O, Kasparek P, Bumba L, Klein OD, Sedlacek R, Sebo P, Prochazka J, Osicka R. Intrinsically disordered proteins drive enamel formation via an evolutionarily conserved self-assembly motif. Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):E1641-E1650.

Dong LF, Kovarova J, Bajzikova M, Bezawork-Geleta A, Svec D, Endaya B, Sachaphibulkij K, Coelho AR, Sebkova N, Ruzickova A, Tan AS, Kluckova K, Judasova K, Zamecnikova K, Rychtarcikova Z, Gopalan V, Andera L, Sobol M, Yan B, Pattnaik B, Bhatraju N, Truksa J, Stopka P, Hozak P, Lam AK, Sedlacek R, Oliveira PJ, Kubista M, Agrawal A, Dvorakova-Hortova K, Rohlena J, Berridge MV, Neuzil J. Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells. Elife. 2017 Feb 15;6. pii: e22187.

Kasparek P, Ileninova Z, Zbodakova O, Kanchev I, Benada O, Chalupsky K, Brattsand M, Beck IM, Sedlacek R. KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype. PLoS Genet. 2017 Jan 17;13(1):e1006566.

Seipold L, Damme M, Prox J, Rabe B, Kasparek P, Sedlacek R, Altmeppen H, Willem M, Boland B, Glatzel M, Saftig P. Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein. Biochim Biophys Acta. 2017 Jan;1864(1):217-230.

2016

Fafilek B, Krausova M, Vojtechova M, Pospichalova V, Tumova L, Sloncova E, Huranova M, Stancikova J, Hlavata A, Svec J,Sedlacek R, Luksan O, Oliverius M, Voska L, Jirsa M, Paces J, Kolar M, Krivjanska M, Klimesova K, Tlaskalova-Hogenova H,Korinek V: Troy, a Tumor Necrosis Factor Receptor Family Member, Interacts With Lgr5 to Inhibit Wnt Signaling in Intestinal Stem Cells. Gastroenterology 2012. [pubmed] [doi]

Jirouskova M, Zbodakova O, Gregor M, Chalupsky K, Sarnova L, Hajduch M, Ehrmann J, Jirkovska M, Sedlacek R: Hepatoprotective Effect of MMP-19 Deficiency in a Mouse Model of Chronic Liver Fibrosis. PLoS One 2012 7(10): e46271. [pubmed] [doi]

Kasparek P, Krenek P, Buryova H, Suchanova S, Beck IM, Sedlacek R: Transgenic mouse model expressing tdTomato under involucrin promoter as a tool for analysis of epidermal differentiation and wound healing. Transgenic Res 201221(3): 683-9. [pubmed] [doi]

Kollmus H, Post R, Brielmeier M, Fernández J, Fuchs H, McKerlie C, Montoliu L, Otaegui PJ, Rebelo M, Riedesel H, Ruberte J,Sedlacek R, de Angelis MH, Schughart K: Structural and functional concepts in current mouse phenotyping and archiving facilities. J Am Assoc Lab Anim Sci 2012 51(4): 418-35. [pubmed]

Vrbacký M, Kovalčíková J, Chawengsaksophak K, Beck IM, Mráček T, Nůsková H, Sedmera D, Papoušek F, Kolář F, Sobol M, Hozák P, Sedlacek R, Houštěk J: Knockout of Tmem70 alters biogenesis of ATP synthase and leads to embryonal lethality in mice. Hum Mol Genet 2016.

2014

Prukova D, Ileninova Z, Antosova B, Kasparek P, Gregor M, Sedlacek R: Transgenic reporter mice with promoter region of murine LRAT specifically marks lens and meiosis spermatocytes. Physiol Res 2014.

2012

Jirouskova M, Zbodakova O, Gregor M, Chalupsky K, Sarnova L, Hajduch M, Ehrmann J, Jirkovska M, Sedlacek R: Hepatoprotective Effect of MMP-19 Deficiency in a Mouse Model of Chronic Liver Fibrosis. PLoS One 2012 7(10): e46271.