Internationally recognized scientist in the field of parasitology, acting at the Faculty of Science, Charles University.
Recent publications
Makki A., Rada P, Žárský V., Kereiche S., Kovacik L., Novotny M., Jores T., Rapaport D., Tachezy J. 2019 Triplet-pore structure of a highly divergent TOM complex of hydrogenosomes in Trichomonas vaginalis. PLoS Biology. 17(1):e3000098. doi: 10.1371/journal.pbio.3000098
Štáfková J., Rada P., Meloni D., Žárský V., Smutná T., Zimmann N., Harant K., Pompach P., Hrdý I., Tachezy J. 2018. Dynamic secretome of Trichomonas vaginalis: Case study of β-amylases. Molecular and Cellular Proteomics, 2018 Feb;17(2):304-320. doi: 10.1074/mcp.RA117.000434
Nývltová, E., Šuťák R., Žárský V., Harant K., Hrdý I., Tachezy J. 2017. Lateral gene transfer of p-cresol- and indole-producing enzymes from environmental bacteria to Mastigamoeba balamuthi. Environmental Microbiology, 2017 Mar;19(3):1091-1102. doi: 10.1111/1462-2920.13636.
Nývltová E., Stairs C.W., Hrdý I., Rídl J., Mach J., Pačes J., Roger A.J., Tachezy J. 2015. Lateral gene transfer and gene duplication played a key role in the evolution of Mastigamoeba balamuthi hydrogenosomes. Mol Biol Evol, Apr;32(4):1039-55. doi: 10.1093/molbev/
Nývltová E., Šuták R, Šedinová M., Harant K, Hrdý I., Pačes, J., Vlček, Č., Tachezy, J. 2013. NIF-type iron-sulfur cluster assembly system is duplicated and distributed in the mitochondria and cytosol of Mastigamoeba balamuthi. Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7371-6. doi: 10.1073/pnas.1219590110.
Horváthová L., Šafaříková L., Hrdý I., Basler M., Tang P., Shin J. W., Tachezy J. 2012. Transcriptomic identification of iron-regulated and iron-independent gene copies within the heavily duplicated Trichomonas vaginalis genome. Genome Biol. Evol. 4:905-17
Šmíd O, Matušková A, Harris SR, Kučera T, Novotný M, Horváthová L, Hrdý I, Kutějová E, Hirt RP, Embley TM, Janata J, Tachezy J. 2008. Reductive evolution of the mitochondrial processing peptidases of the unicellular parasites Trichomonas vaginalis and Giardia intestinalis. PLoS Pathogens, 4(12):e1000243.
Doležal, P., Likic, P., Tachezy, J., Lithgow, T. 2006. Evolution of the molecular machines for protein import into mitochondria. Science, 313:314-318.
Hrdý I., Hirt R., Doležal P., Bardoňová L., Tachezy J.*, Embley M*. 2004. Trichomonas hydrogenosomes contain the NADH dehydrogenase module of mitochondrial complex I. Nature, 432: 618-622. *Corresponding authors.
Tovar, J., Leon-Avila, G., Sanchez, L., Sutak, R., Tachezy, J., van der Giezen, M., Hernandez, M., Muller, M., and Lucocq, J. M. (2003). Mitochondrial remnant organelles of Giardia function in iron-sulphur protein maturation. Nature, 426:172-176.