The project is focused on the structure-functional basis of gaseous molecule signalling.
- Characterization of mammalian isoforms of NOS and HO, more precise definition of the NO and CO role in the individual physiological and pathophysiological processes.
- Determination of the complete structure of the NOS holoenzyme
- Study of the reactivity and catalytic characteristics of bacterial NOSoxy-like proteins, clarification of their ability to bind different compounds, i.e. at close quarters of the haem (as it is in the L-Arg analogues in the mammalian NOS or in the iron ligands)
More info at http://biocev.lf1.cuni.cz