The Structure-Function Basis of Signalling with Gaseous Molecules

The Structure-Function Basis of Signalling with Gaseous Molecules

Ing. Ivan Mikula, Ph.D.

Ing. Ivan Mikula, Ph.D. — Project head

About us

The project is focused on the structure-functional basis of gaseous molecule signalling.

Objectives:

  • Characterization of mammalian isoforms of NOS and HO, more precise definition of the NO and CO role in the individual physiological and pathophysiological processes.
  • Determination of the complete structure of the NOS holoenzyme
  • Study of the  reactivity and catalytic characteristics of bacterial NOSoxy-like proteins, clarification of their ability to bind different compounds, i.e. at close quarters of the haem (as it is in the L-Arg analogues in the mammalian NOS or in the iron ligands)

 

More info at http://biocev.lf1.cuni.cz

Team

Ing. Ivan Mikula, Ph.D.

Ing.
Ivan Mikula, Ph.D.

Member of the Board, Head of Group The Structure-Function Basis of Signalling with Gaseous Molecules

ivan.mikula@lf1.cuni.cz
+420325873022