The important factor supporting integration of biomaterials with the tissue of recipient in biomedical applications is immobilization of biologically active substances on the biomaterial surface. Our research activities are focused on development of technologies for surface modifications. The studied coating technologies are tools for controlled introduction of biological active substances (such as specific peptides or growth factors) on the surface of porous as well as nonporous implants.
In this way we aim to modulate the interaction of the implant surface with the host tissue in the place of implantation (e.g. adsorption of proteins, adhesion, proliferation or differentiation of cells or surface endothelization). We also focus on preparation of 3D macroporous polymer scaffolds for cell transplantation and for tissue regeneration and replacement applications.
- Surface modification of biomaterials for increase of their bioactivity
- Preparation of 3D polymer scaffolds for tissue engineering applications
- Coatings deposited on the surface of biomaterials via physical interactions
- Coatings based on self-associated complexes of polyelectrolytes enabling delivery of growth factors and cytokines into the place of implantation. (layer-by-layer approach)
- Coatings based on deposition of colloidal solutions of functionalized block copolymers containing specific peptide sequences and growth factors
- Coatings deposited on the surface of biomaterials via polymerization techniques
- Multifunctional combined coatings prepared by controlled polymerization of fibrinogen containing growth factors and antithrombogenic agens. Deposition of organized fibrin nanostructures growing from the surface by a catalytic action of the surface-bound thrombin on the solution containing fibrinogen and subsequent covalent and non-covalent immobilization of growth factors
- Multifunctional combined coatings prepared by advanced polymerization techniques (surface initiated controlled polymerizations) yielding grafted polymer brushes with bioactive species (antitrombogenic agens, specific peptide sequences, aptamers)
- Polyelectrolyte particles based on natural polymers as carriers for delivery of growth factors and cytokines