The project focuses on the study of new types of polymer conjugates of biologically active compounds intended for the treatment of various types of oncological, infectious and inflammatory diseases with potential use in human medicine.
The structure of the proposed conjugates is based on biocompatible hydrophilic or amphiphilic polymeric carriers differing in composition, functional group valences, or polymer chain architecture to which various biologically active species – cancerostatic, peptide or protein antigens, antibodies, nucleic acids, inhibitors, etc. – are bound via stable or biodegradable linkages.
The application portfolio of the developed materials can be further expanded by incorporating fluorescent, radioisotopic or contrast agents into their structures, which can be used in the diagnosis of tumor diseases or in the image-guided surgery. Modern synthetic, polymerization and bioconjugation processes leading to the preparation of highly defined tailored materials as well as sophisticated physico-chemical and analytical techniques enabling their precise characterization will be used in this project.
Aims of the project
- Development of new types of water-soluble and self-assembling supramolecular polymer carriers of drugs and contrast agents for the therapy and diagnostics of oncological and inflammatory diseases
- Development of advanced antigen-based vaccines consisting of a nanoparticle-forming polymeric carrier, a peptide antigen and a synthetic adjuvant for the prophylaxis of infectious diseases and the personalized therapy of cancers
- Development of high-molecular-weight polymer carriers of cancerostatics and immuno-therapeutics for combined chemo / immune therapy of oncological diseases
- Development of new types of synthetic polycations and reactive hydrophilic polymers enabling the complexation or covalent binding of nucleic acids applicable in the treatment of oncological and hereditary diseases