Ing. Zdeněk Trachtulec, Ph.D.

Ing. Zdeněk Trachtulec, Ph.D.

Head of Group Germ Cell Development

M.Sc. in enzyme engineering, University of Chemical Technology in Prague

Institute of Molecular Genetics v.v.i., Academy of Sciences of the Czech Republic, Prague

Dept. Microbiology and Immunology, University of Miami School of Medicine, USA

Dept. Immunogenetics, Max-Planck-Institute for Biology in Tuebingen, Germany

Ph.D. in molecular genetics, Faculty of Science, Charles University in Prague

Organization ΦΒΔ, Miami, USA (Outstanding International Scholar)

Recent publications

2021

Mihola O, Landa V, Pratto F, Brick K, Kobets T, Kusari F, Gasic S, Smagulova F, Grey C, Flachs P, Gergelits V, Tresnak K, Silhavy J, Mlejnek P, Camerini-Otero RD, Pravenec M, Petukhova GV, Trachtulec Z: Rat PRDM9 shapes recombination landscapes, duration of meiosis, gametogenesis, and age of fertility. BMC Biol 2021 19(1): 86.

Tsyklauri O, Niederlova V, Forsythe E, Prasai A, Drobek A, Kasparek P, Sparks K, Trachtulec Z, Prochazka J, Sedlacek R, Beales P, Huranova M, Stepanek O: Bardet-Biedl Syndrome ciliopathy is linked to altered hematopoiesis and dysregulated self-tolerance. EMBO Rep 2021, e50785.

2020

Kusari F, Mihola O, Schimenti JC, Trachtulec Z: Meiotic epigenetic factor PRDM9 impacts sperm quality of hybrid mice. Reproduction 2020 160(1): 53-64.

Mihola O, Kobets T, Krivankova K, Linhartova E, Gasic S, Schimenti JC, Trachtulec Z: Copy-number variation introduced by long transgenes compromises mouse male fertility independently of pachytene checkpoints. Chromosoma 2020 129(1): 69-82

2019

Mihola O, Pratto F, Brick K, Linhartova E, Kobets T, Flachs P, Baker CL,
Sedlacek R, Paigen K, Petkov PM, Camerini-Otero RD, Trachtulec Z:
Histone methyltransferase PRDM9 is not essential for meiosis in male
mice. Genome Research 2019 29:1078-1086

2017

Mihola O, Trachtulec Z: A Mutation of the Prdm9 Mouse Hybrid Sterility Gene Carried by a Transgene. Folia Biol (Praha) 2017 63(1): 27-30.

2016

Balcova M, Faltusova B, Gergelits V, Bhattacharyya T, Mihola O, Trachtulec Z, Knopf C, Fotopulosova V, Chvatalova I, Gregorova S, Forejt J: Hybrid Sterility Locus on Chromosome X Controls Meiotic Recombination Rate in Mouse. PLoS Genet 2016 12(4): e1005906.

Balcova M, Faltusova B, Gergelits V, Bhattacharyya T, Mihola O, Trachtulec Z, Knopf C, Fotopulosova V, Chvatalova I, Gregorova S, Forejt J. Hybrid Sterility Locus on Chromosome X Controls Meiotic Recombination Rate in Mouse. PLoS Genet. 2016 Apr 22;12(4):e1005906. doi: 10.1371/journal.pgen.1005906.

2015

Baker CL, Petkova P, Walker M, Flachs P, Mihola O, Trachtulec Z, Petkov PM, Paigen K: Multimer Formation Explains Allelic Suppression of PRDM9 Recombination Hotspots. PLoS Genet 2015 11(9): e1005512.

2014

Flachs P, Bhattacharyya T, Mihola O, Piálek J, Forejt J, Trachtulec Z. Prdm9 incompatibility controls oligospermia and delayed fertility but no selfish transmission in mouse intersubspecific hybrids. PLoS One. 2014 Apr 22;9(4):e95806. doi: 10.1371/journal.pone.0095806.

Flachs P, Bhattacharyya T, Mihola O, Piálek J, Forejt J, Trachtulec Z: Prdm9 incompatibility controls oligospermia and delayed fertility but no selfish transmission in mouse intersubspecific hybrids. PLoS One 2014 9(4): e95806.

2012

Flachs P, Mihola O, Simecek P, Gregorova S, Schimenti JC, Matsui Y, Baudat F, de Massy B, Pialek J, Forejt J, Trachtulec Z: Interallelic and Intergenic Incompatibilities of the Prdm9 (Hst1) Gene in Mouse Hybrid Sterility. PLoS Genetics 2012 8(11): e1003044.

Forejt J, Pialek J, Trachtulec Z: Hybrid male sterility genes in the mouse subspecific crosses. Evolution of the House Mouse. In: Macholan M, Ed. Macholan M, at all, Cambridge University Press 2012, 482-503.

2009

Mihola, O., Trachtulec, Z., Vlček, C., Schimenti, J.C., Forejt, J: A mouse speciation gene encodes a meiotic Histone H3 methyltransferase. Science 2009; 323:373—375.

Mihola O, Trachtulec Z, Vlcek C, Schimenti JC, Forejt J: A mouse speciation gene encodes a meiotic histone H3 methyltransferase. Science 2009 323(5912): 373-5.

2008

Gregorová S, Divina P, Storchova R, Trachtulec Z, Fotopulosova V, Svenson KL, Donahue LR, Paigen B, Forejt J: Mouse consomic strains: exploiting genetic divergence between Mus m. musculus and Mus m. domesticus subspecies. Genome Res 2008 18(3): 509-15.

Trachtulec Z, Vlcek C, Mihola O, Gregorova S, Fotopulosova V, Forejt J: Fine haplotype structure of a chromosome 17 region in the laboratory and wild mouse. Genetics 2008 178(3): 1777-84.

2007

Mihola O, Forejt J, Trachtulec Z: Conserved alternative and antisense transcripts at the programmed cell death 2 locus. BMC Genomics 2007 8: 20.

2005

Trachtulec T, Mihola O, Vlček Č, Himmelbauer H, Pačes V, Forejt J: Positional cloning of the Hybrid sterility 1 gene: fine genetic mapping and evaluation of two candidate genes. Biological Journal of the Linnean Society 2005 84(3): 637-641.

Vyskocilova M, Trachtulec Z, Forejt J, Pialek J: Does geography matter in hybrid sterility in house mice? Biological Journal of the Lennean Society 2005 84(3): 663-674.