Postdoctoral Researcher - Antibiotic resistance group in Laboratory for Biology of Secondary Metabolism

Postdoctoral Researcher - Antibiotic resistance group in Laboratory for Biology of Secondary Metabolism

Antibiotics that target translation are important tools in the fight against bacterial infections. However, their widespread use has led to the emergence of antibiotic-resistant bacteria that pose a serious threat to public health. ABCF proteins are a recently discovered family of proteins that confer resistance to a wide range of antibiotics that target translation. ABCF proteins function by interacting directly with the ribosome and interfering with antibiotic binding. In addition to resistance determinants acquired through horizontal gene transfer, bacterial genomes harbor putative antibiotic resistance ABCF proteins that may contribute to innate resistance or serve as a reservoir for specialized resistance determinants.

This research project will focus on understanding the physiological functions of genome-encoded ABCF proteins in Clostridium difficile and Enterococcus faecalis and identifying the mechanisms that may lead to specialization of genome-encoded ABCF proteins for antibiotic resistance. The candidate will work closely with clinical microbiologists who have an extensive collection of clinical isolates with sequenced genomes and well-characterized resistance profiles. This collection will form the basis for the search for different variants of ABCF proteins to be further characterized genetically, biochemically and with OMICs approaches.

More info HERE

Deadline: 15.01.2024

Contact
Mgr. Gabriela Balíková-Novotná, Ph.D.
+420325873605
gnovotna@biomed.cas.cz