Postdoctoral fellow - Laboratory of Molecular Pathogenetics (apply through MERIT Postdoctoral Fellowship Programme)
The successful postdoc fellow will be based in the Laboratory of Molecular Pathogenetics part of the Institute of Biotechnology of the Czech Academy of Sciences located atBIOCEV for up to 2.5 years. The post is located in Vestec in the Central Bohemia region in the Czech Republic.
The Postdoctoral fellow will join the research team of the Laboratory of Molecular Pathogeneticsthat is focused on epigenetic and transcriptional regulations during embryonic development. Understanding the different ways in which epigenetic signals and transcription factor networks govern self-renewal, cell specification, differentiation, and reprogramming is a key step for advances in cell-based therapy and perspectives for medicine. Using mouse models, we aim to investigate how elimination and miss-expression of key transcription factors affect epigenetic landscapes and downstream targets during embryonic development, and lead to predispositions and pathogenesis of disease. We use Cre/loxP and global gene expression profiling (RNA sequencing), single cell RNA sequencing, CUT&RUN chromatin profiling, FACS, confocal microscopy, immunohistochemistry, and in situ hybridization to evaluate molecular phenotypes and regulatory mechanisms.
More info HERE