Open PhD position: Molecular Pathogenetics - Endocrine pancreas development at single cell level
Understanding the different ways in which epigenetic signals and transcription factor networks govern self-renewal, cell specification, differentiation, and reprogramming is a key step for advances in cell-based therapy and perspectives for medicine.
Using mouse models, we aim to investigate how elimination and miss-expression of selected transcription factors affect epigenetic landscapes and downstream targets during embryonic development, particularly pancreatic development. We will use Cre/loxP and global gene expression profiling (RNA sequencing), single cell sequencing, CUT&RUN chromatin profiling, FACS, confocal microscopy, immunohistochemistry, and in situ hybridization to evaluate molecular phenotypes and regulatory mechanisms.
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