RNDr. Eduard Brynda, CSc.

RNDr. Eduard Brynda, CSc.

Member of BIOCEV Internal Scientific Board, Co-ordinator of research programme Biomaterials and Tissue Engineering

Head of the Department of Polymer Membranes at the Institute of Macromolecular Chemistry AS CR.

E. Brynda has long-term experience in basic research of interfaces between synthetic materials and biological media and interactions of synthetic materials with blood and cells, and in applied research focused on the applications of biomedical materials in tissue engineering, cardiovascular surgery, and biosensors gained during his employment in IMC since 1971, in Centre for Cell Therapy and Tissue Repair, Prague, CR since 2000, engagement at University of Utah, Salt Lake City, USA as a Visiting Associated Professor of Bioengineering 1988 and 1990, and during repeated one month - stays in Hahn-Meitner Institut Berlin GmbH, Berlin, Germany in 1991-93.

He has managed various national research projects associating several institutions, e.g., Controlled Immobilization of Interfacing Biomolecular Assemblies 2002-2004, Nanobiotechnology for creation of interfaces between biological media and artificial entities 2005-2007, Surface plasmon biosensors and protein chips for medical diagnostics 2007-2011, and as a Czech partner of international projects, such as, Grating coupler biosensors (Project of Bilateral Cooperation between Czech Republic and Germany, 1997-1999), Membrane Coated Optical Grating Coupler Sensors (EUREKA EU 947 MEMOCS, 1995-1998), Blood Compatible Interfaces Based on Molecular Systems of Alternating Monolayers of Albumin and Heparin (PECO, BIOMED 1, Concerted Action HEART, EC 1995-1996.

He has utilized his extended knowledge in the field as a supervisor of PhD students at European Graduate College “Advanced Polymeric Materials, Preparation, Characterization, Application”, Dresden, Germany, 2000-2005, and a member of Expert Group on Mapping of Research and Development Excellence in Europe in the Areas of Life Sciences and Nanotechnologies, EC Brussels 2001-2003.

Recent publications


Kaplan O, Hierlemann T, Krajewski S, Kurz J, Nevoralová M, Houska M, Riedel T, Riedelová Z, Zárubová J, Wendel HP, Brynda E. Low-thrombogenic fibrin-heparin coating promotes in vitro endothelialization. J Biomed Mater Res A. 2017 Nov;105(11):2995-3005.

Lísalová H, Brynda E, Houska M, Víšová I, Mrkvová K, Song XC, Gedeonová E, Surman F, Riedel T, Pop-Georgievski O, Homola J. Ultralow-Fouling Behavior of Biorecognition Coatings Based on Carboxy-Functional Brushes of Zwitterionic Homo-and Copolymers in Blood Plasma: Functionalization Matters. Anal Chem. 2017 Mar 21;89(6):3524-3531.

Bacakova M, Pajorova J, Stranska D, Hadraba D, Lopot F, Riedel T, Brynda E, Zaloudkova M, Bacakova L. Protein nanocoatings on synthetic polymeric nanofibrous membranes designed as carriers for skin cells. Int J Nanomedicine. 2017 Feb 9;12:1143-1160.

Riedel T, Hageneder S, Surman F, Pop-Georgievski O, Noehammer C, Hofner M, Brynda E, Rodriguez-Emmenegger C, Dostálek J. Plasmonic Hepatitis B Biosensor for the Analysis of Clinical Saliva. Anal Chem. 2017 Mar 7;89(5):2972-2977.


Vaisocherová-Lísalová H, Surman F, Víšová I, Vala M, Špringer T, Ermini ML, Šípová H, Šedivák P, Houska M, Riedel T, Pop-Georgievski O, Brynda E, Homola J. Copolymer Brush-Based Ultralow-Fouling Biorecognition Surface Platform for Food Safety. Anal Chem. 2016 Nov 1;88(21):10533-10539.

Riedelová-Reicheltová Z, Brynda E, Riedel T. Fibrin nanostructures for biomedical applications. Physiol Res. 2016 Oct 20;65(Supplementum 2):S263-S272

Kaplan O, Zárubová J, Mikulová B, Filová E, Bártová J, Bačáková L, Brynda E. Enhanced Mitogenic Activity of Recombinant Human Vascular Endothelial Growth Factor VEGF121 Expressed in E. coli Origami B (DE3) with Molecular Chaperones. PLoS One. 2016 Oct 7;11(10):e0163697.

Riedel T, Surman F, Hageneder S, Pop-Georgievski O, Noehammer C, Hofner M, Brynda E, Rodriguez-Emmenegger C, Dostálek J. Hepatitis B plasmonic biosensor for the analysis of clinical serum samples. Biosens Bioelectron. 2016 Nov 15;85:272-279.

Bacakova M, Musilkova J, Riedel T, Stranska D, Brynda E, Zaloudkova M, Bacakova L. The potential applications of fibrin-coated electrospun polylactide nanofibers in skin tissue engineering. Int J Nanomedicine. 2016 Feb 25;11:771-89.


Vaisocherová H, Brynda E, Homola J. Functionalizable low-fouling coatings for label-free biosensing in complex biological media: advances and applications. Anal Bioanal Chem. 2015 May;407(14):3927-53.


Riedel T, Majek P, Rodriguez-Emmenegger C, Brynda E. Surface plasmon resonance: advances of label-free approaches in the analysis of biological samples. Bioanalysis. 2014;6(24):3325-36.

Tischer T, Rodriguez-Emmenegger C, Trouillet V, Welle A, Schueler V, Mueller JO, Goldmann AS, Brynda E, Barner-Kowollik C. Photo-patterning of non-fouling polymers and biomolecules on paper. Adv Mater. 2014 Jun 25;26(24):4087-92.

Chlupac J, Filova E, Havlikova J, Matejka R, Riedel T, Houska M, Brynda E, Pamula E, Rémy M, Bareille R, Fernandez P, Daculsi R, Bourget C, Bacakova L, Bordenave L. The gene expression of human endothelial cells is modulated by subendothelial extracellular matrix proteins: short-term response to laminar shear stress. Tissue Eng Part A. 2014 Aug;20(15-16):2253-64.

Chlupáč J, Filová E, Riedel T, Houska M, Brynda E, Remy-Zolghadri M, Bareille R, Fernandez P, Daculsi R, Bourget C, Bordenave L, Bačáková L. Attachment of human endothelial cells to polyester vascular grafts: pre-coating with adhesive protein assemblies and resistance to short-term shear stress. Physiol Res. 2014;63(2):167-77.

Riedel T, Rodriguez-Emmenegger C, de los Santos Pereira A, Bědajánková A, Jinoch P, Boltovets PM, Brynda E. Diagnosis of Epstein-Barr virus infection in clinical serum samples by an SPR biosensor assay. Biosens Bioelectron. 2014 May 15;55:278-84.

Vaisocherová H, Ševců V, Adam P, Špačková B, Hegnerová K, de los Santos Pereira A, Rodriguez-Emmenegger C, Riedel T, Houska M, Brynda E, Homola J. Functionalized ultra-low fouling carboxy- and hydroxy-functional surface platforms: functionalization capacity, biorecognition capability and resistance to fouling from undiluted biological media. Biosens Bioelectron. 2014 Jan 15;51:150-7.

Filová E, Brynda E, Riedel T, Chlupáč J, Vandrovcová M, Svindrych Z, Lisá V, Houska M, Pirk J, Bačáková L. Improved adhesion and differentiation of endothelial cells on surface-attached fibrin structures containing extracellular matrix proteins. J Biomed Mater Res A. 2014 Mar;102(3):698-712.


Riedel T, Riedelová-Reicheltová Z, Májek P, Rodriguez-Emmenegger C, Houska M, Dyr JE, Brynda E. Complete identification of proteins responsible for human blood plasma fouling on poly(ethylene glycol)-based surfaces. Langmuir. 2013 Mar 12;29(10):3388-97.


Rodriguez-Emmenegger C, Brynda E, Riedel T, Houska M, Šubr V, Bologna Alles A, Hasan E,. Gautrot JE, Huck WTS: Polymer Brushes Showing Non-Fouling in Blood Plasma Challenge the Currently Accepted Design of Protein Resistant Surfaces. Macromol.Rapid.Com., 2011, 32, 952–957

Rodriguez-Emmenegger C, Avramenko OA, Brynda E, Bologna Alles A: Polymer brushes emerging as a new platform for direct detection of food pathogen in real samples. BIOSENSORS & BIOELECTRONICS 2011, 26, 4545-4551


Riedel T, Brynda E, Dyr JE, Houska M: Controlled preparation of thin fibrin films immobilized at solid surfaces. J.Biomed.Mater.Res., 2009, 88A, 437-447

Filová E, Brynda E, Riedel T, Bačáková L, Chlupáč J, Lisá V, Houska M, Dyr JE: Vascular Endothelial Cells on Two- and Three-Dimensional Fibrin Assemblies for Biomaterial Coatings. J.Biomed.Mater.Res., 2009, 90, 55-69