The project focuses on molecular processes and regulatory mechanisms involved in the adaptation, aging and cell death of yeast populations and in the response of populations to different stresses. The project focuses mainly on multicelluar populations such as biofilms and colonies that are capable of differentiation.
The main topics currently studied included identification of specific metaboli processes and defense strategies important for long-term developoment of colonies and biofilms and different roles of celluar organeles (e. g. mitochondria, peroxisomes and autophagosomes). Different approaches are used in the studies that include, in addition to a wide spectrum of methods of microbiology, biochemistry and cell and molecular biology, unique techniques developed in the laboratory for investigating yeast populations. These techniques include, for example, specific approaches of two photon confocal microscopy. The research in the project takes advantage from of the close collaboration with project 2. 1. 5., which also includes collaboration with the G. Gilfillan group in Oslo, Norway of Czech-Norwegian grant funding.
Potential for cooperation
The expertise that we offer involves physiology and cell biology of yeast populations, including an analysis of selected stress defense processes. We also offer cooperation in the field of immobilized yeast populations covered by our patent "Modification method of detection yeast strain" No 305223, which enables detection of different chemicals that have been applied in Disposable kit for detection of the content of cupric (Cu2+) ions in drinking waters and industrial wastewaters developed with LentiKat's a.s.