Mgr. Klára Hlouchová, Ph.D.
Vystudovala biochemii na Přírodovědecké fakultě UK, postdoktorské studium absolvovala na University of Colorado Boulder USA pod vedením prof. Shelley Copleyové, kde se věnovala evoluci metabolických cest. Nyní působí na katedře buněčné biologie PřF UK.
Další informace pouze v anglickém jazyce
During my PhD at IOCB (Czech Republic) I worked as a member of a team studying enzyme glutamate carboxypeptidase II (GCPII), an important pharmaceutical target.
My doctoral studies therefore introduced me to protein biochemistry and structural biology in a potentially applied research context even though it also involved studies of the evolutionary aspects of the protein of interest. I later joined the group of Prof. Shelley Copley at University of Colorado Boulder (USA) for my postdoctoral research to study evolution of proteins and metabolic pathways.
My research stay was supported by the CIRES postdoctoral fellowship for planetary metabolism. We studied how bacteria manage to evolve new metabolic pathways and regulate ecosystems in response to the changes in their environment. However, some of the projects also introduced me to very early evolution of protein and RNA catalysts as part of collaborative grants supported by the NASA Astrobiology Institute. The latter inspired me the most in my future research back in Prague.
I started my independent research in Synthetic Biology in 2017. Our group is interested in various aspects of protein evolution ranging from astrobiology and origins of life to protein engineering and synthetic life. Our research is currently supported by international collaborative grants (such as HFSP and VW Stiftung) as well as the Primus grant from the Charles University.
Rozhovor s Klárou Hlouchovou pro portál Vedavyzkum.cz
