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Obrázek mastigamoeby pořízený v IMCF (BIOCEV) se dostal na titulní stránku časopisu Environmental Microbiology

publikováno: 15.3.2017

Publikační úspěch zaznamenala skupina prof. Tachezyho, jejichž článek “Lateral gene transfer of p-cresol- and indol-producing enzymes from environmental bacteria to Mastigamoeba balamuthi” byl uveden v “Highlights” časopisu Enviromental Microbiology. Jeden z obrázků použitých v publikaci, nasnímaný na FIB-SEM mikroskopu v servisní laboratoři IMCF, se dostal až na titulní stránku daného vydání časopisu.

Více informací o publikaci:

Lateral gene transfer of p-cresol- and indol-producing enzymes from environmental bacteria to Mastigamoeba balamuthi: Eva Nývltová, Robert Šuťák, Vojtěch Žárský, Karel Harant, Ivan Hrdý, Jan Tachezy; Department of Parasitology, Charles University, Faculty of Science, Biocev

p-Cresol is an odorous toxic compound that is produced in oxygen-limited environments such as animal intestines, soil environments, and marine and estuarine sediments. The production of p-cresol is restricted to a few species of anaerobic bacteria, and its production by eukaryotic microbes has not been observed. Unexpectedly, we discovered that Mastigamoeba balamuthi, an amoeba living in low-oxygen habitats, produces p-cresol at bacteriostatic concentrations. We identified a key enzyme, 4-hydroxyphenylacetate decarboxylase, with a unique structure (a glycyl radical enzyme fused with the activating enzyme in M. balamuthi), and we elucidated the pathway mediating the tyrosine-to-4-hydroxyphenylacetate conversion. We propose that p-cresol production provides M. balamuthia competitive advantage over other microflora in its native anaerobic habitats.

For further details, the readers are referred to the article by Gonzalez and colleagues on pp. 847-848 of this issue. The anaerobic protist Mastigamoeba balamuthi acquired a bacterial weapon by lateral gene transfer. Scanning electron micrograph of an axenic culture.