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Postdoc position – Molecular aspects of normal and malignant hematopoiesis

published: 5.12.2017

BIOCEV StopkaLab

The lab focuses on molecular aspects of normal and malignant hematopoiesis; with an expertise in the next generation sequencing, gene expression, flow cytometry, microscopy and mouse transgenic models.

We are looking for open-minded person with solid training from previous lab. Welcome is an expertise in molecular and cellular biology, genetics, and/or biochemistry. We offer a salary scale based on performance and two-year extendable contract. Our lab is located in a modern science building and offers superb research facilities. Applicants are encouraged to provide english CV version and a short list of professional goals all fitting a single page.

See below specifications of available projects:

  • Project I: translation of genetics to clinical decisions in Myelodysplastic syndrome (MDS). Current work of our lab has concluded that patients with MDS treated by DNA methylation inhibitor Azacitidine (AZA) are either able to prevent progression or develop resistence and transform to acute leukemia while acquiring additional somatic mutations. The project aims to delineate genetic but also epigenetic mechanisms of therapeutic AZA resistance by utilizing up-to-date sequencing tools.
  • Project II: epigenetic mechanisms in cancer monitoring. Previous work of our lab has established use of microRNAs as disease biomarkers in patients with aggressive solid tumors including breast cancer or malignant lymphomas. The project aims to delineate molecular function of microRNAs in distant tissues using mouse models and ex vivo transplanted human tumors to immunodefficient mice.

The position is available from January 2018.

Contact: Applicatns are encouraged to provide english CV version to tstopka@lf1.cuni.cz