we would like to inform you about PhD position available in the Laboratory of Transgenic Models of Diseases that is part of BIOCEV research program 1 focused on elucidation of the biological role of Tiki, Wnt-specific Metalloproteases
The project focuses on TIKI1 and especially TIKI2 (TRABD2A and TRABD2B genes) whose biological role in mammals is still purely understood. TIKIs function as negative regulators of the Wnt signaling pathway, mediating cleavages of N-terminal residues of a subset of Wnt proteins. Phylogenetic analysis shows that Tiki1 and Tiki2 orthologues are highly conserved among vertebrate and mammalian species although the Tiki1 is missing in rodents. The role of Tiki proteases will be studied in mouse and human systems and the work will start with the analysis of our TIKI2 –deficient mice. The aim of this study is to describe the pathophysiologic roles of TIKI2 (TIKI1).
Candidate’s profile (requirements)
M.Sc. (Mgr.) degree or equivalent in molecular/cellular biology or biochemistry, a good command of English, independent thinking but also team player, strong interest in basic research and experimental work, ability to work with animals (rodents – training will be provided).
For more information and application details please visit http://www.img.cas.cz/studium/phd-program/