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Open Position – PhD Student – Molecular aspects of normal and malignant hematopoiesis

published: 5.12.2017

BIOCEV StopkaLab

Laboratory
The lab focuses on molecular aspects of normal and malignant hematopoiesis; with an expertise in the next generation sequencing, gene expression, flow cytometry, microscopy and mouse transgenic models.

Project of translation of genetics to clinical decisions in Myelodysplastic syndrome (MDS). Current work of our lab has concluded that MDS patients treated by DNA methylation inhibitor Azacitidine are able to achieve durable therapeutic response however all patients subsequently transform to acute leukemia while they acquire new somatic mutations or acquire Azacitdine resistence via epigenetic mechanisms. The project aims to delineate molecular mechanisms of therapeutic resistance and decipher tools for efficient timing of the therapeutic switch and how this can be tuned by using the NGS approach.

We are looking for open-minded person with interests in genetics and biochemistry that is keen on learning new methodologies and gaining unprecedented expertize such as in the next generation sequencing, epigenetic technologies or cellular phenotyping and culture systems.

We offer friendly and kind environment at modern science building with superb research facilities and salary scale based on performance with three-year extendable contract.

This position is available from January 2018.

Contact
Applicants are encouraged to provide english CV version and a short list of professional goals all fitting a single page to tstopka@lf1.cuni.cz