Review of “The ISWI ATPase Smarca5 (Snf2h) is required for proliferation and differentiation of hematopoietic stem and progenitor cells” from STEM CELLS by Stuart P. Atkinson
The assembly and remodeling of chromatin aided by imitation switch (ISWI) proteins facilitate essential cellular tasks such as DNA replication, DNA repair, and transcription. Of the two vertebrate ISWIs (Smarca1 and Smarca5), studies indicate that the general function of the hematopoietic system requires Smarca5 activity [1, 2] with an added importance to erythroid cells.
As conventional knockout (KO) of murine Smarca5 is lethal early in embryonic development , the laboratories of Tomas Stopka (Charles University, Vestec, Czech Republic) and Arthur I. Skoultchi (Albert Einstein College of Medicine, New York, USA) have developed a new conditional KO mouse model to study the role of Smarca5 in hematopoiesis. Their findings, reported in STEM CELLS, now suggest that Smarca5 loss interferes with the proliferation and differentiation of hematopoietic stem cells (HSCs) and multipotent progenitors (MPPs) and modulates the proliferation and survival of fully committed erythroid progenitors (EPs) .
Full article: http://www.stemcellsportal.com/article-scans/new-model-system-describes-importance-smarca5-hematopoiesis?utm_source=iContact&utm_medium=email&utm_campaign=RMW&utm_content=RMW+June+27+v.2