Infrafrontier is “The European Infrastructure for Phenotyping and Archiving of Model Mammalian Genomes”.
The goal of consortium Infrafrontier is to define the function of all mouse genes and in this way model the gene functions in man. As mouse and man share about 95 % of their genetic information, in this respect mouse represents an excellent model for studying the function of human diseases.
The full membership of BIOCEV in consortium Infrafrontier was confirmed on December 11, 2009. This scientific programme will include a unique centre under preparation, Czech Phenogenomics Centre. Besides BIOCEV, only the Ministry of Education, Youth and Sports of the Czech Republic has become a member of this consortium.
Participation in the scientific programme of Infrafrontier will enable all Czech scientists (not only those engaged in BIOCEV) to move to the front line of basic and applied research in genetics and biomedicine, together with renowned international research centres. BIOCEV will thus become a unique centre conducting research with results having potential principal impact on the success of therapeutic strategies in a number of serious human disorders such as infertility or cancer.
Infrafrontier consists of two parts – Phenomefrontier for systemic phenotyping and Archivefrontier for archiving and distribution.
Effective from January 1st, 2010 the Institute of Molecular Genetics AS CR v.v.i. became a new Partner to EMMA, the European Mouse Mutant Archive. EMMA, a non-profit repository for the collection, archiving and distribution of relevant mutant strains essential for basic biomedical research, was set up to create capacity for well co-ordinated archiving and distribution of mouse models. EMMA network is building the archiving and distribution platform that as Archivefrontier constitutes one two pillars of INFRAFRONTIER, the European infrastructure for phenotyping and archiving of model mammalian genomes. This new ESFRI-based infrastructure will organise two complementary and linked infrastructure networks for large-scale and comprehensive phenotyping and archiving of mouse models serving the European genetics and biomedical research community for the benefit of human health.